Observational studyJournal of the American Heart Association2020
Incremental Prognostic Impact of Peripheral Microvascular Endothelial Dysfunction on the Development of Ischemic Stroke.
Observational study in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06389149 (Leg Exercise Assistive Paddling), which is not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Leg Exercise Assistive Paddling (LEAP) Therapy for Peripheral Artery Disease
Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Peripheral Microvascular and Endothelial Dysfunction as Predictors of Cognitive Decline and Small Vessel Disease: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Association between peripheral and coronary microvascular function and the impact of myocardial bridging.Physiological reports · 2025Article
- Prognostic value of endothelial activation and stress index in mechanical thrombectomy for patients with acute ischemic stroke.Frontiers in aging neuroscience · 2025Article
- Peripheral Endothelial Dysfunction Is Associated With Incident Major Depressive Disorder.Journal of the American Heart Association · 2024Article
- Lower glomerular filtration rate after mild stroke induces cognitive impairment by causing endothelial dysfunction.Scientific reports · 2024Observational
- Coronary microvascular dysfunction in heart failure patients.Frontiers in cardiovascular medicine · 2023Review
- Early Signs of Microvascular Endothelial Dysfunction in Adolescents with Newly Diagnosed Essential Hypertension.Life (Basel, Switzerland) · 2022Article
- Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage.Current medical science · 2022Review
- Mechanisms and Clinical Implications of Endothelial Dysfunction in Arterial Hypertension.Journal of cardiovascular development and disease · 2022Review
- Peripheral microvascular dysfunction is associated with plaque progression and adverse long-term outcomes in heart transplant patients.ESC heart failure · 2021Article
- Impact of Peripheral Microvascular Endothelial Dysfunction on White Matter Hyperintensity.Journal of the American Heart Association · 2021Article
- Prognostic impact and clinical outcomes of coronary flow reserve and hyperaemic microvascular resistance.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2021Article
- Risk Stratification of Patients With NonObstructive Coronary Artery Disease Using Resistive Reserve Ratio.Journal of the American Heart Association · 2021Observational
- Article
- Incremental Prognostic Impact of Peripheral Microvascular Endothelial Dysfunction on the Development of Ischemic Stroke.Journal of the American Heart Association · 2020Observational
- Contributing Factors to Endothelial Dysfunction in Individuals with Spinal Cord Injuries.Pulse (Basel, Switzerland)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Peripheral microvascular endothelial dysfunction (PMED) has been linked to an increased risk of cardiovascular events, but there is a lack of information characterizing the predictive value of PMED for future risk of ischemic stroke (IS). Methods and Results This retrospective observational cohort study enrolled 637 patients who underwent non-invasive microvascular endothelial function assessment using reactive hyperemia peripheral arterial tonometry. Reactive hyperemia peripheral arterial tonometry index ≤2 was defined as PMED. Of 280 patients with PMED, 12 (4.3%) patients developed IS, compared with only 4 (1.1%) of 357 patients without PMED during a median follow-up of 5.3 years. Patients with PMED had lower IS-free survival compared with patients without PMED (log-rank
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.