ArticleJournal of clinical neurology (Seoul, Korea)2020
South Korean Study to Prevent Cognitive Impairment and Protect Brain Health Through Lifestyle Intervention in At-Risk Elderly People: Protocol of a Multicenter, Randomized Controlled Feasibility Trial.
Article in Journal of clinical neurology (Seoul, Korea), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multidomain intervention for dementia prevention: a scoping review.Frontiers in neurologyPooled it
- Trial
- Polygenicity and APOE ε4 shape response to intervention in mild cognitive impairment.Alzheimer's research & therapy · 2025Trial
- A digitally supported multimodal lifestyle program to promote brain health among older adults (the LETHE randomized controlled feasibility trial): study design, progress, and first results.Alzheimer's research & therapy · 2024Trial
- Trial
- Impact of Multidomain Lifestyle Intervention on Cerebral Cortical Thickness and Serum Brain-Derived Neurotrophic Factor: the SUPERBRAIN Exploratory Sub-study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Trial
- Trial
- Trial
- SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health via Behavioral, Optimized, Organized Movement therapy (SUPERBRAIN-BOOM) in Mild Cognitive Impairment: Protocol for a Multicenter, Randomized Controlled Feasibility Trial.Journal of clinical neurology (Seoul, Korea) · 2026Article
- Association of the Big Five personality traits with cognitive decline: a 24-week multidomain intervention study.Frontiers in psychiatry · 2026Article
- Exploring the Association Between Physical Fitness Components and Cognitive Function in Older Korean Adults: The SUPERBRAIN Exploratory Sub-study.Dementia and neurocognitive disorders · 2026Article
- The Effectiveness of VR-Based Cognitive Training Program for Mild Cognitive Impairment: A Pilot Study.Dementia and neurocognitive disorders · 2025Article
- Alzheimer disease seen through the lens of sex and gender.Nature reviews. Neurology · 2025Review
- [Diagnosis and Treatment of Alzheimer's Disease: Current Update].Journal of the Korean Society of Radiology · 2025Review
- Effects of oral nutritional supplements plus mature silkworm pill on cognitive function in Korean adults with mild cognitive impairment: a 12-week randomized blinded clinical trial.Frontiers in nutrition · 2025Article
- SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through Multidomain interventions via facE-to-facE and video communication plaTforms in mild cognitive impairment (SUPERBRAIN-MEET): Protocol for a Multicenter Randomized Controlled Trial.Dementia and neurocognitive disorders · 2024Article
- Social participation and risk of developing dementia.Nature aging · 2023Review
- Mediterranean Diet, Ketogenic Diet or MIND Diet for Aging Populations with Cognitive Decline: A Systematic Review.Life (Basel, Switzerland) · 2023Review
- Impact of a multidomain lifestyle intervention on white matter integrity: the SUPERBRAIN exploratory sub-study.Frontiers in aging neuroscience · 2023Article
- Effects of the multidomain intervention with nutritional supplements on cognition and gut microbiome in early symptomatic Alzheimer's disease: a randomized controlled trial.Frontiers in aging neuroscience · 2023Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
background and purposeThe prevalence of dementia is increasing in South Korea. Multidomain interventions may be useful for preventing dementia. Such programs need to be disseminated to elderly Koreans throughout the country. We have developed programs of the SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN), which consists of a facility-based multidomain intervention (FMI) program and a home-based multidomain intervention (HMI) program suitable for elderly Koreans. We aim to determine the feasibility of the SUPERBRAIN programs before a large-scale randomized controlled trial.
methodsWe will recruit 150 participants among those without dementia aged 60-79 years with at least 1 modifiable dementia risk factor. They will be randomly assigned in a 1:1:1 ratio to the FMI, HMI, and the waiting-list control arm. The 6-month multidomain intervention consists of management of metabolic and vascular risk factors, cognitive training and social activity, physical exercise, nutritional guidance, and motivational enhancement programs. The primary outcomes are adherence and retention rates and changes in the total scale index score of the Repeatable Battery for the Assessment of Neuropsychological Status from baseline to the study end. The main secondary outcomes are disability, depressive symptoms, quality of life, vascular risk factors, physical performance, nutritional assessment, and motivation questionnaire. There will be an exploratory evaluation of neurotrophic, neurodegeneration, and neuroinflammation factors, microbiome, telomere length, electroencephalography, and neuroimaging measures.
conclusionsThe results obtained will provide information on the applicability of these multidomain intervention programs to at-risk elderly people.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.