ArticleMolecular genetics & genomic medicine2020
Genetic polymorphisms of IL1RN were associated with lumbar disk herniation risk in a Chinese Han population.
Article in Molecular genetics & genomic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.
- Incidence of and risk factors for lumbar disc herniation with radiculopathy in adults: a systematic review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Pooled it
- Genetic polymorphisms of IL1RN were associated with lumbar disk herniation risk in a Chinese Han population.Molecular genetics & genomic medicine · 2020Article
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7 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundInterleukin (IL)-1 is a cytokine superfamily, which involved in the inflammatory process and immune response in human body. IL-1 receptor antagonist (IL1RN) has been found to be associated with risk of lumbar disk herniation (LDH) in Finland samples. However, to date, there was no investigation focus on the polymorphisms of IL1RN in Chinese Han LDH patient. MATERIALS AND
methodsWe conducted a case-control study based on 498 LDH patients and 463 controls. Five single-nucleotide polymorphisms (SNPs) in IL1RN were genotyped.
resultsAs a result, we found that the AG and GG genotypes of rs3181052 were associated with decreased risk LDH under the dominant model (OR = 0.74, 95%CI: 0.57-0.96, p = .025). In the stratification analysis, the frequency of the "A" allele of rs17042888 was significantly lower in elder LDH cases than in controls (OR = 0.723, 95%CI: 0.544-0.961, p = .025). In addition, the AG and AA genotypes of rs17042888 were associated with decreased risk of LDH in elder group under the dominant model (OR = 0.69, 95%CI: 0.49-0.98, p = .038). The GG genotype of rs315919 was identified have correlation with decreased risk of LDH in elder group under the recessive model (OR = 0.60, 95%CI: 0.37-0.97, p = .034).
conclusionsOur data showed that IL1RN may be a susceptibility gene for risk of LDH in Chinese Han population.
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