ArticleEnvironmental science and pollution research international2020
Innovative health risk assessments of heavy metals based on bioaccessibility due to the consumption of traditional animal medicines.
Article in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- A novel bioaccessibility-based probabilistic risks assessment of potentially toxic elements (PTEs) in earthworm.Frontiers in pharmacology · 2024Article
- Analysis of non-carcinogenic health risk assessment of elemental impurities in vitamin C supplements.Iranian journal of basic medical sciences · 2023Article
- Article
- Integrating Multi-Type Component Determination and Anti-Oxidant/-Inflammatory Assay to Evaluate the Impact of Pre-Molting Washing on the Quality and Bioactivity of Cicadae Periostracum.Molecules (Basel, Switzerland) · 2022Article
- Novel bioavailability-based risk assessment of Cd in earthworms and leeches utilizing in vitro digestion/Caco-2 and MDCK cells.Environmental science and pollution research international · 2022Article
- Ecological and health risk assessment of heavy metals in soil and Chinese herbal medicines.Environmental geochemistry and health · 2022Article
- Novel Integrated Tiered Cumulative Risk Assessment of Heavy Metals in Food Homologous Traditional Chinese Medicine Based on a Real-Life-Exposure Scenario.Frontiers in pharmacology · 2022Article
- Tracing the heavy metals zinc, lead and nickel in banana shrimp (Penaeus merguiensis) from the Persian Gulf and human health risk assessment.Environmental science and pollution research international · 2021Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Few studies reported the extent of heavy metal accumulation in traditional Chinese medicines (TCMs). Currently, oral bioaccessibility of lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), and copper (Cu) present in traditional animal medicines was investigated with physiologically based extraction test-extracted in vitro model. We are the first to develop a health risk assessment strategy by combinational analysis of bioaccessible heavy metal levels to calculate target hazard quotient (THQ), target hazard index (THI) and cancer risk (CR), which has capacity to evaluate the heavy metal associated heath risk of traditional animal medicines. To precisely acquire a realistic risk assessment, questionnaire data was adopted to measure the frequency and duration of the exposure to traditional animal medicines, and the safety factor was highlighted as well. Our data revealed that the bioaccessibility of Hg was the lowest among the five heavy metals. After the adjustment with the bioaccessibility of each heavy metal to target hazard index (THI) values, excitingly, the results manifested that the consumption of traditional animal medicines might not exert an unacceptable health risk in a broad community. In addition, the CR values of As and Pb indicated that the risk of developing cancers was quite lower than their acceptable levels in the clinic.
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