Evidence map›Paper›PMID 32319048›Full record

ArticleJournal of endocrinological investigation2020

Ovarian 25OH-vitamin D production in young women affected by polycystic ovary syndrome.

R Mioni, M Gallea, M Granzotto, F Dassie, M Parolin, P Maffei, D Faggian, F De Marchi, P Litta, R Vettor

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Article in Journal of endocrinological investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

R MioniDepartment of Medicine, Clinica Medica 3, Azienda Ospedaliera di Padova, University of Padua, Via Giustiniani 2, 35128, Padua, PD, Italy. roberto.mioni@aopd.veneto.it.ORCID http://orcid.org/0000-0002-5647-1157
M GalleaDepartment of Medicine, Clinica Medica 3, Azienda Ospedaliera di Padova, University of Padua, Via Giustiniani 2, 35128, Padua, PD, Italy.
M GranzottoDepartment of Medicine, Clinica Medica 3, Azienda Ospedaliera di Padova, University of Padua, Via Giustiniani 2, 35128, Padua, PD, Italy.
F DassieDepartment of Medicine, Clinica Medica 3, Azienda Ospedaliera di Padova, University of Padua, Via Giustiniani 2, 35128, Padua, PD, Italy.
M ParolinDepartment of Medicine, Clinica Medica 3, Azienda Ospedaliera di Padova, University of Padua, Via Giustiniani 2, 35128, Padua, PD, Italy.
P MaffeiDepartment of Medicine, Clinica Medica 3, Azienda Ospedaliera di Padova, University of Padua, Via Giustiniani 2, 35128, Padua, PD, Italy.
D FaggianDepartment of Laboratory Medicine, Azienda Ospedaliera di Padova, University of Padua, Via Giustiniani 2, 35128, Padua, Italy.
F De MarchiDepartment of Women's and Children's Health, Azienda Ospedaliera di Padova, University of Padua, Via Giustiniani 2, 35128, Padua, Italy.
P LittaDepartment of Women's and Children's Health, Azienda Ospedaliera di Padova, University of Padua, Via Giustiniani 2, 35128, Padua, Italy.
R VettorDepartment of Medicine, Clinica Medica 3, Azienda Ospedaliera di Padova, University of Padua, Via Giustiniani 2, 35128, Padua, PD, Italy.
University of Padua · IT

Funding

University of Padua A00000D150 SICDE PPR/08
6 · The paper itself

Abstract

introductionVitamin D is involved in the regulatory mechanisms of ovarian function and is frequently low in PCOS patients. Since obesity and hyperinsulinemic state negatively influenced vitamin D levels, therefore, we evaluated the production of vitamin D at the ovarian level only in lean and normoinsulinemic PCOS subjects. Basal, GnRH analogue-induced ovarian production of 25OH-vitamin D (VitD) and a direct sampling at ovarian vein level were investigated.

methodsBasal and GnRH analogue-induced hormone levels were evaluated at peripheral level in 45 subjects, aged 18-39 years, and in 22 healthy women with age- and BMI-matched as controls. In 12 PCOS patients, undergoing laparoscopy, a venous sampling at both peripheral and ovarian level was further done. All subjects presented low VitD levels, appropriate to the season and with no difference between PCOS and control subjects.

resultsGnRH analogue significantly stimulated plasma LH, FSH, 17-OHP and estradiol secretion (p from < 0.05 to < 0.001 vs basal levels), whereas no effect was observed on both serum AMH and VitD concentrations in all groups. A significant difference (p < 0.006), between peripheral and ovarian veins, was observed in both AMH and estradiol levels in PCOS subjects, while no gradient of VitD was detected.

conclusionsAll patients presented with low VitD levels. The absence of any VitD variation, both at basal and after GnRH analogue administration, or at peripheral-ovarian vein gradient, suggests no pituitary-ovarian axis involvement in VitD production or its direct ovarian production in lean and normoinsulinemic PCOS subjects.

Indexed as

AdolescentAdultBlood Specimen CollectionCase-Control StudiesFemaleFollicle Stimulating HormoneHumansHydroxycholecalciferolsLuteinizing HormoneOvaryPolycystic Ovary SyndromeVitamin DYoung AdultFollicle Stimulating HormoneHydroxycholecalciferolsLuteinizing HormoneVitamin DGnRH analogueOvarian vein samplingOvary functionPCOSVitamin D

Identifiers

PMID32319048
OpenAlexW3016412628

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.