ArticleJournal of endocrinological investigation2020
Compared with classic Hashimoto's thyroiditis, chronic autoimmune serum-negative thyroiditis requires a lower substitution dose of L-thyroxine to correct hypothyroidism.
Article in Journal of endocrinological investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Systemic inflammatory indices and the FT4/TSH ratio in Hashimoto's thyroiditis: predictive and prognostic implications.Irish journal of medical science · 2026Article
- Serum Negative Chronic Autoimmune Thyroiditis (SN-CAT): A Case Report of Three Siblings Without Familial History of Autoimmune Thyroid Diseases (ATDs).Clinical case reports · 2026Article
- Immunopathogenesis, Diagnosis, and Treatment of Hashimoto's Thyroiditis.Archives of internal medicine research · 2026Article
- Serum-negative chronic thyroiditis: an insidious nosographic entity cause of hypothyroidism, goiter and difficult thyroidectomy.Endocrine · 2025Article
- Evaluating the diagnostic efficiency of ultrasound and serum autoantibodies in Hashimoto's thyroiditis: a cross-sectional study.Scientific reports · 2025Article
- Visfatin (rs3801266) and Adiponutrin (rs738409) gene single nucleotide polymorphisms in patients with Hashimoto's thyroiditis.Molecular biology reports · 2025Article
- Prediction of Seronegative Hashimoto's thyroiditis using machine learning models based on ultrasound radiomics: a multicenter study.BMC immunology · 2025Article
- Hashimoto's thyroiditis in an Egyptian cohort: clinical, functional, and ultrasonographic features with insights into nodule risk.Frontiers in endocrinology · 2025Article
- Article
- Relationship between maternal obesity and first-trimester TSH in women with negative anti-TPO antibodies.European thyroid journal · 2024Article
- Structural and functional differences in auto-antibody positive compared to auto-antibody negative hypothyroid patients with chronic thyroiditis.Scientific reports · 2023Article
- Unexplained Hyperthyrotropinemia: A Biochemical and Clinical Challenge.Journal of clinical medicine · 2023Article
- AI-Assisted Ultrasound for the Early Diagnosis of Antibody-Negative Autoimmune Thyroiditis.Journal of multidisciplinary healthcare · 2023Review
- Seronegative phenotype in a pediatric population with Hashimoto's thyroiditis.Hormones (Athens, Greece) · 2022Article
- Thyroid and heart, a clinically relevant relationship.Journal of endocrinological investigation · 2021Review
- A diffuse large B-cell thyroid lymphoma presented as a compressive goiter in a young woman with no evidence of Hashimoto's thyroiditis.Clinical case reports · 2021Article
- Climate and air pollution exposure are associated with thyroid function parameters: a retrospective cross-sectional study.Journal of endocrinological investigation · 2021Article
- Precision Medicine in Autoimmune Thyroiditis and Hypothyroidism.Frontiers in pharmacology · 2021Review
- Clinical Observation of Levothyroxine Sodium Combined with Selenium in the Treatment of Patients with Chronic Lymphocytic Thyroiditis and Hypothyroidism and the Effects on Thyroid Function, Mood, and Inflammatory Factors.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- The Human Microbiota in Endocrinology: Implications for Pathophysiology, Treatment, and Prognosis in Thyroid Diseases.Frontiers in endocrinology · 2020Review
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSerum-negative-chronic-autoimmune-thyroiditis (SN-CAT) is considered a milder variant of classic Hashimoto's thyroiditis (CHT). However, its prevalence remains unknown and it is still unclear whether SN-CAT behaves differently in terms of L-thyroxine (LT4) substitution treatment of hypothyroidism. Aims of this study were to estimate the prevalence of SN-CAT in a large series of hypothyroid patients and to compare LT4 requirements in hypothyroid patients with SN-CAT and CHT.
methodsFive-hundred-eighty-one consecutive patients with primary-autoimmune-hypothyroidism were enrolled in a cross-sectional study. LT4 requirements and thyroid-volume changes were longitudinally evaluated in 49 hypothyroid patients with SN-CAT and in 98 sex and age-matched hypothyroid patients with CHT.
resultsIn our series the prevalence of SN-CAT was 20.8%. At diagnosis, patients in the CHT and SN-CAT groups had similar male/female ratio, age and BMI, while serum TSH and thyroid-volume were significantly greater in the CHT group. In the longitudinal study, during a follow-up of 8.9 ± 4.6 years, 8 out of 49 (16.3%) SN-CAT patients developed positive tests for of circulating TPO-Ab and/or Tg-Ab. Thyroid-volume significantly decreased in CHT patients, but not in those with SN-CAT. The maximum daily substitution dose of LT4 was smaller in SN-CAT patients as compared with the CHT ones. Multivariate analysis showed that age, BMI, basal TSH and thyroid antibody status independently and significantly predicted the maximum daily substitution dose of LT4.
conclusionsSN-CAT accounts for a significant proportion of patients with autoimmune hypothyroidism. Compared with hypothyroid patients diagnosed with CHT, the SN-CAT ones require smaller doses of LT4 to correct their hypothyroidism.
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