Evidence map›Paper›PMID 32319015›Full record

ArticleActa neurologica Belgica2021

Neuroanatomical associations of depression, anxiety and apathy neuropsychiatric symptoms in patients with Alzheimer's disease.

Abd Elazeim Abdalla Mohamed Nour, Yun Jiao, Gao-Jun Teng, Alzheimer’s Disease Neuroimaging Initiative

Abstract read
PubMed Publisher
In one paragraph

Article in Acta neurologica Belgica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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  15. Mild behavioral impairment is associated with progression to Alzheimer's disease: A clinicopathological study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Abd Elazeim Abdalla Mohamed NourJiangsu Key Laboratory of Molecular Imaging and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Ding Jiaqiao Rd., Nanjing, 210009, China.
Yun JiaoJiangsu Key Laboratory of Molecular Imaging and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Ding Jiaqiao Rd., Nanjing, 210009, China.
Gao-Jun TengJiangsu Key Laboratory of Molecular Imaging and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Ding Jiaqiao Rd., Nanjing, 210009, China. gjteng@seu.edu.cn.
Alzheimer’s Disease Neuroimaging Initiative
Zhongda Hospital Southeast University · CN

Funding

Jiangsu Provincial Medical Youth Talent (CN) QNRC2016810Jiangsu Provincial Special Program of Medical Science BL2013029Major State Basic Research Development Program of China 2013CB733800Major State Basic Research Development Program of China 2013CB733803Major State Basic Research Development Program of China 973 ProgramNatural Science Foundation of Jiangsu Province BE2016782Natural Science Foundation of Jiangsu Province BK20141342The National Natural Science Foundation of China 61601155The National Natural Science Foundation of China 81230034The National Natural Science Foundation of China 81271739The National Natural Science Foundation of China 81501453The National Natural Science Foundation of China 81520108015
6 · The paper itself

Abstract

Depression, anxiety and apathy are 'common neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD). We aimed to find regional gray matter (GM) volume difference of these symptoms, in AD patients compared to AD control, and investigate possible associations of GM atrophy with cognitive covariant. Study subjects were retrieved from the Alzheimer's Disease Neuroimaging Initiative database. Thirty-five participants are AD control, 27 AD patients with anxiety, 19 with depression and 24 with apathy, ages ≥ 55.1 years. Recruited subjects had an assessment of their clinical and structural MRI data. GM differences and clinical data were analyzed using voxel-based morphometry and ANOVA with Scheffe post hoc test, respectively. We found significant GM volumes differences in the left insula, left parahippocampal, posterior cingulate and the bilateral putamen in the anxiety group. The results also revealed that the right parahippocampal, Brodmann area 38 and the middle frontal gyrus were significant in patients with depression. Significant results were with a p < 0.05, corrected with AlphaSim program for multiple comparisons. The left insula had a strong negative association with Clinical Dementia Rate Sum of Boxes and Alzheimer's Disease Assessment Scale-cognitive subscale-13 items in anxiety and apathy groups. The difference in GM density in the left insula and hippocampus plays a crucial role in depression, anxiety and apathy NPS and outline precise approaches to test these symptoms.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAnxietyApathyBrainDepressionFemaleHumansMagnetic Resonance ImagingMaleMental DisordersMiddle AgedOrgan SizePositron-Emission TomographyAlzheimer’s diseaseAnxietyApathyDepressionLeft insulaNeuropsychiatric symptoms

Identifiers

PMID32319015
OpenAlexW3016476347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.