Evidence map›Paper›PMID 32318793›Full record

Observational studyArchives of toxicology2020

Combined effect of polymorphisms of MTHFR and MTR and arsenic methylation capacity on developmental delay in preschool children in Taiwan.

Yu-Mei Hsueh, Ying-Chin Lin, Chi-Jung Chung, Ya-Li Huang, Ru-Lan Hsieh, Pai-Tsang Huang, Mei-Yi Wu, Horng-Sheng Shiue, Ssu-Ning Chien, Chih-Ying Lee and 3 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Archives of toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Yu-Mei HsuehDepartment of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Ying-Chin LinDepartment of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Chi-Jung ChungDepartment of Public Health, College of Public Health, China Medical University, Taichung, Taiwan.
Ya-Li HuangDepartment of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Ru-Lan HsiehDepartment of Physical Medicine and Rehabilitation, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Pai-Tsang HuangDepartment of Occupational Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Mei-Yi WuDivision of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Horng-Sheng ShiueDepartment of Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Ssu-Ning ChienSchool of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan.
Chih-Ying LeeDepartment of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Ming-I LinDepartment of Pediatrics, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Shu-Chi MuDepartment of Pediatrics, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Chien-Tien SuDepartment of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. ctsu@tmu.edu.tw.
Taipei Medical University · TWChang Gung University · TWChina Medical University · TWTaipei Medical University-Shuang Ho Hospital · TWWan Fang Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR) are related to cognitive dysfunction and mental disability. These genes, along with folate and vitamin B

Indexed as

Child DevelopmentPolymorphism, Genetic5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseAge FactorsArsenicBiomarkersCase-Control StudiesChildChild, PreschoolDevelopmental DisabilitiesDose-Response Relationship, DrugFemaleFolic AcidHumansMaleMethylation5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseArsenicBiomarkersFolic AcidMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanMTR protein, humanVitamin B 12ArsenicArsenic methylationDevelopmental delayMTHFRMTRPolymorphism

Identifiers

PMID32318793
OpenAlexW3017149814

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.