Evidence map›Paper›PMID 32318783›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

Early-phase [

Leonie Beyer, Alexander Nitschmann, Henryk Barthel, Thilo van Eimeren, Marcus Unterrainer, Julia Sauerbeck, Ken Marek, Mengmeng Song, Carla Palleis, Gesine Respondek and 27 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 61 citations in OpenAlex.

  1. Network-dependent remote effects and local tau burden jointly shape neuronal dysfunction in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  2. Dynamic [Molecular neurodegeneration · 2026
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  3. Feasibility of short imaging protocols for [European journal of nuclear medicine and molecular imaging · 2026
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  4. Review
  5. Review
  6. Review
  7. Quantitative Measurement of Tau Burden in a Dual-Time-Window Dynamic PET Imaging Protocol with [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  8. Exploring the origins of frequent tau-PET signal in vermal and adjacent regions.European journal of nuclear medicine and molecular imaging · 2025
    Article
  9. Multi-parametric [European journal of nuclear medicine and molecular imaging · 2025
    Article
  10. Early-phaseEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  11. Article
  12. Article
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  14. Review
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  16. Article
  17. Article
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  19. Measurement of Cerebral Perfusion Indices from the Early Phase of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 11 institutions in 3 countries.

Leonie BeyerDepartment of Nuclear Medicine, University Hospital of Munich LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.
Alexander NitschmannDepartment of Nuclear Medicine, University Hospital of Munich LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.
Henryk BarthelDepartment of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
Thilo van EimerenCognitive Neuroscience, Institute for Neuroscience and Medicine (INM-3), Research Centre Juelich, Juelich, Germany.
Marcus UnterrainerDepartment of Nuclear Medicine, University Hospital of Munich LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.
Julia SauerbeckDepartment of Nuclear Medicine, University Hospital of Munich LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.
Ken MarekInviCRO, LLC, Boston, MA, USA.
Mengmeng SongDepartment of Nuclear Medicine, University Hospital of Munich LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.
Carla PalleisDepartment of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany.
Gesine RespondekDepartment of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany.
Jochen HammesDepartment of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.
Michael T BarbeDepartment of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Özgür OnurDepartment of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Frank JessenGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Dorothee SaurDepartment of Neurology, University of Leipzig Medical Center, Leipzig, Germany.
Matthias L SchroeterClinic for Cognitive Neurology, University of Leipzig, Leipzig, Germany.
Jost-Julian RumpfCenter for Memory Disorders, University Hospital Cologne, Cologne, Germany.
Michael RullmannDepartment of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
Andreas SchildanDepartment of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
Marianne PattDepartment of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
Bernd NeumaierInstitute of Neuroscience and Medicine, Nuclear Chemistry (INM-5), Forschungszentrum Juelich GmbH, Juelich, Germany.
Olivier BarretInviCRO, LLC, Boston, MA, USA.
Jennifer MadoniaInviCRO, LLC, Boston, MA, USA.
David S RussellInviCRO, LLC, Boston, MA, USA.
Andrew W StephensLife Molecular Imaging GmbH, Berlin, Germany.
Sigrun RoeberCenter for Neuropathology and Prion Research, University Hospital of Munich, LMU Munich, Munich, Germany.
Jochen HermsGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Kai BötzelDepartment of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany.
Johannes LevinDepartment of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany.
Joseph ClassenDepartment of Neurology, University of Leipzig Medical Center, Leipzig, Germany.
Günter U HöglingerGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Peter BartensteinDepartment of Nuclear Medicine, University Hospital of Munich LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.
Victor VillemagneDepartment of Molecular Imaging & Therapy, Austin Health, Heidelberg, VIC, Australia.
Alexander DrzezgaDepartment of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.
John SeibylInviCRO, LLC, Boston, MA, USA.
Osama SabriDepartment of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
Matthias BrendelDepartment of Nuclear Medicine, University Hospital of Munich LMU Munich, Marchioninstraße 15, 81377, Munich, Germany. matthias.brendel@med.uni-muenchen.de.
Leipzig University · DELudwig-Maximilians-Universität München · DEUniversity Hospital Cologne · DEGerman Center for Neurodegenerative Diseases · DEElucid Bioimaging · USInvicro (United States) · USLMU Klinikum · DEForschungszentrum Jülich · DEMunich Cluster for Systems Neurology · DEUniversity of Cologne · DEUniversity of Melbourne · AU

Funding

Deutsche Forschungsgemeinschaft EXC 2145 SyNergy - ID 390857198German Federal Ministriy of Education and Research BMBF, 01EK1605A HitTauNOMIS foundation FTLD project
6 · The paper itself

Abstract

purposeSecond-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [

methodsTwenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkinson's disease, multi-system atrophy, Parkinson's disease, frontotemporal dementia) and received a dynamic [

resultsHighest agreement with [

conclusionEarly-phase imaging of [

Indexed as

Alzheimer DiseaseTomography, X-Ray ComputedBiomarkersFluorodeoxyglucose F18HumansPositron-Emission TomographyBiomarkersFluorodeoxyglucose F18[18F]PI-2620Neuronal injuryPerfusionPETTau

Identifiers

PMID32318783
PMCPMC7567714
OpenAlexW3016409070

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.