ArticleAnimal models and experimental medicine2020
The use of 5-fluorouracil in the prevention of tendon adhesions: A systematic review.
Article in Animal models and experimental medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 4 citations in OpenAlex.
- Can pirfenidone prevent tendon adhesions? An experimental study in rats.Joint diseases and related surgery · 2023Article
- Neutralization of excessive levels of active TGF-β1 reduces MSC recruitment and differentiation to mitigate peritendinous adhesion.Bone research · 2023Article
- Effects of 5-fluorouracil released from different prosthetic meshes on post-operative adhesion formation in rats.Northern clinics of Istanbul · 2022Article
- The use of 5-fluorouracil in the prevention of tendon adhesions: A systematic review.Animal models and experimental medicine · 2020Article
- Transcriptomic Profiling Reveals NF-κB-Associated Immune Regulatory Signatures Underlying the Regenerative Effects of Hypoxia-Preconditioned Tendon Stem Cell-Derived Extracellular Vesicles.BioFactors (Oxford, England)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis systematic review aims to study the effectiveness of 5-fluorouracil (5FU) in the reduction of tendon adhesions postsurgical repair.
methodA systematic review was performed involving four databases, Cochrane, PubMed, MEDLINE, and Embase, looking for evidence of at least Level I or Level II (according to NHMRC) in the use of 5FU in tendon repairs in human or animal studies.
resultsAcross the four databases 546 articles were identified. Of these 12 were identified as relevant, with a further two being excluded after in depth review.
conclusionsNine of the 10 studies showed that 5FU was effective at reducing tendon adhesions in their respective animal studies. One of the 10 studies showed no significant change compared to the control group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.