Evidence map›Paper›PMID 32318648›Full record

ArticleJournal of the Endocrine Society2020

Novel

Valiyaparambil Pavithran Praveen, Asmahane Ladjouze, Kay-Sara Sauter, Annie Pulickal, Efstathios Katharopoulos, Mafalda Trippel, Aurel Perren, Amit V Pandey, Christa E Flück

Open access · goldAbstract read
In one paragraph

Article in Journal of the Endocrine Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Association of theJournal of clinical medicine · 2022
    Article
  4. Article
  5. Becoming female: Ovarian differentiation from an evolutionary perspective.Frontiers in cell and developmental biology · 2022
    Review
  6. Approach to the Virilizing Girl at Puberty.The Journal of clinical endocrinology and metabolism · 2021
    Review
  7. Journal of genetics · 2021
    Article
  8. Review
  9. Inhibition of placental CYP19A1 activity remains as a valid hypothesis for 46,XX virilization in P450 oxidoreductase deficiency.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Valiyaparambil Pavithran PraveenDepartment of Endocrinology, Amrita Institute of Medical Sciences, Kochi, Kerala, India.
Asmahane LadjouzeDepartment of Pediatrics, CHU Bab El Oued, Algiers, Algeria.
Kay-Sara SauterDepartment of Pediatrics, Division of Pediatric Endocrinology, Diabetology and Metabolism University Children's Hospital Bern, Switzerland, and Department of Biomedical Research, University of Bern, Bern, Switzerland.
Annie PulickalDepartment of Endocrinology, Amrita Institute of Medical Sciences, Kochi, Kerala, India.
Efstathios KatharopoulosDepartment of Pediatrics, Division of Pediatric Endocrinology, Diabetology and Metabolism University Children's Hospital Bern, Switzerland, and Department of Biomedical Research, University of Bern, Bern, Switzerland.
Mafalda TrippelInstitute of Pathology, University of Bern, Bern, Switzerland.
Aurel PerrenInstitute of Pathology, University of Bern, Bern, Switzerland.
Amit V PandeyDepartment of Pediatrics, Division of Pediatric Endocrinology, Diabetology and Metabolism University Children's Hospital Bern, Switzerland, and Department of Biomedical Research, University of Bern, Bern, Switzerland.
Christa E FlückDepartment of Pediatrics, Division of Pediatric Endocrinology, Diabetology and Metabolism University Children's Hospital Bern, Switzerland, and Department of Biomedical Research, University of Bern, Bern, Switzerland.ORCID 0000-0002-4568-5504
University of Bern · CHAmrita Institute of Medical Sciences and Research Centre · INCentre Hospitalo-Universitaire Bab El Oued · DZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextThe steroidogenic enzyme aromatase (CYP19A1) is required for estrogen biosynthesis from androgen precursors in the ovary and extragonadal tissues. The role of aromatase, and thus estrogens, is best illustrated by genetic variations of the

objectiveThe objective of this work is to characterize novel DESIGN SETTING AND PATIENTS: Variants causing aromatase deficiency were suspected in four 46,XX children of African and Indian origin by careful clinical phenotyping. Sequencing of the MAIN OUTCOME MEASURE AND

results

conclusionIn girls, aromatase deficiency usually manifests at birth, but diagnosis may also be made because of abnormal pubertal development or ovarian torsion due to (poly)cystic ovaries. The ovary harboring

Indexed as

aromatase deficiencyCYP19A1disorder of sexual developmentestrogen synthesishyperandrogenismvirilization

Identifiers

PMID32318648
PMCPMC7159065
OpenAlexW3011082140

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.