ArticleEndocrinology, diabetes & metabolism2020
Prevalence of elevated liver enzymes and its association with type 2 diabetes: A cross-sectional study in Bangladeshi adults.
Article in Endocrinology, diabetes & metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 77 citations in OpenAlex.
- Distinct Liver Enzyme Profiles in Non-Diabetic Obesity: Associations with Obesity Severity and Metabolic Dysfunction.Journal of clinical medicine · 2026Article
- Phytochemical Fingerprints by GC-MS, Antidiabetic and Multiorgan Protective Effects of Cucumis sativus Peel: An Integrated In Vitro, In Vivo, and In Silico Study.Chemistry & biodiversity · 2026Article
- Disentangling metabolic impairment in the liver-heart axis: tissue-specific insulin sensitivity in type 2 diabetes.Frontiers in endocrinology · 2026Article
- First trimester hepatic steatosis index as a predictor of gestational diabetes mellitus: a cohort study in Northwestern China.Scientific reports · 2025Article
- Artificial intelligence survival models for identifying relevant risk factors for incident diabetes in Azar cohort population.Health promotion perspectives · 2025Article
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- Elevated liver enzymes and diabetes in the PERSIAN Guilan cohort study.Caspian journal of internal medicine · 2025Article
- Assessment of the Relationship Between Liver Enzymes and Cardiovascular Disease: A Study in Bangladeshi Adults.Endocrinology, diabetes & metabolism · 2024Article
- A case-control regression analysis of liver enzymes in obesity-induced metabolic disorders in South Asian females.PloS one · 2024Article
- Serum Gamma Glutamyl Transferase: Understanding its Contribution as a Potential Predictor of the Occurrence of Type 2 Diabetes.Current diabetes reviews · 2024Review
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- Clover microgreen incorporation in diet-controlled diabetes and counteracted aflatoxicosis of rats.Food science & nutrition · 2023Article
- AST and ALT APRI Scores and Dysglycemia in Saudi Arabia: A Retrospective Population Study.Life (Basel, Switzerland) · 2023Article
- Liver-function parameters are associated with incident hypertension in a large Taiwanese population follow-up study.Journal of human hypertension · 2023Article
- The prevalence and factors associated with obesity and hypertension in university academic staff: a cross-sectional study in Bangladesh.Scientific reports · 2023Article
- Effect of eugenol on lipid profile, oxidative stress, sex hormone, liver injury, ovarian failure, and expression of COX-2 and PPAR-α genes in a rat model of diabetes.Molecular biology reports · 2023Article
- Association between hyperuricemia and chronic kidney disease: a cross-sectional study in Bangladeshi adults.BMC endocrine disorders · 2023Article
- Article
- Hepatic benefits of sodium-glucose cotransporter 2 inhibitors in liver disorders.EXCLI journal · 2023Review
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundType 2 diabetes (T2D) is a major public health concern affecting millions of people worldwide. The relationship between liver enzymes and T2D has been reported in limited studies; however, there is still a lack of evidence for the Bangladeshi population. This study aimed to evaluate the prevalence of elevated liver enzymes and examine its association with the prevalence of T2D in Bangladeshi adults.
methodsA total of 270 individuals (110 diabetic and 160 nondiabetic) were enrolled in the study. Alanine and aspartate aminotransferase (ALT, AST), alkaline phosphatase (ALP) and γ-glutamyltransferase (GGT) activities were measured in blood serum collected from them. T2D was defined as fasting blood glucose (FBG) ≥126 mg/dL or self-reported recent use of insulin or antidiabetic medications. Association between liver enzymes and T2D was evaluated by multinomial logistic regression analysis.
resultsOverall, 61.2% of participants in T2D and 37.1% of participants in the nondiabetes group had at least one or more elevated liver enzymes. The mean concentrations of serum ALT, AST, ALP and GGT were significantly higher in the T2D group compared to the nondiabetes group. The prevalence of elevated liver enzymes was significantly higher in the diabetes group compared to the nondiabetes group (
conclusionsA high prevalence of elevated liver enzymes was observed in subjects having diabetes. Increased serum GGT activity was independently associated with the prevalence of T2D among Bangladeshi adults. More studies of this nature should be carried out in developing countries to get proper insights into the involvement of liver enzymes in T2D.
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