Evidence map›Paper›PMID 32318563›Full record

ArticleFrontiers in bioengineering and biotechnology2020

Engineering Immunomodulatory Biomaterials for Regenerating the Infarcted Myocardium.

Nora Bloise, Isobel Rountree, Collin Polucha, Giulia Montagna, Livia Visai, Kareen L K Coulombe, Fabiola Munarin

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. Angiogenesis: Biological Mechanisms and In Vitro Models.Annals of biomedical engineering · 2025
    Review
  3. Review
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  6. Harnessing Biomaterials for Immunomodulatory-Driven Tissue Engineering.Regenerative engineering and translational medicine · 2023
    Review
  7. Review
  8. Review
  9. Review
  10. Lipidome profiling with Raman microspectroscopy identifies macrophage response to surface topographies of implant materials.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Nora BloiseDepartment of Molecular Medicine, Center for Health Technologies (CHT), INSTM UdR of Pavia, University of Pavia, Pavia, Italy.
Isobel RountreeCenter for Biomedical Engineering, School of Engineering, Brown University, Providence, RI, United States.
Collin PoluchaCenter for Biomedical Engineering, School of Engineering, Brown University, Providence, RI, United States.
Giulia MontagnaDepartment of Molecular Medicine, Center for Health Technologies (CHT), INSTM UdR of Pavia, University of Pavia, Pavia, Italy.
Livia VisaiDepartment of Molecular Medicine, Center for Health Technologies (CHT), INSTM UdR of Pavia, University of Pavia, Pavia, Italy.
Kareen L K CoulombeCenter for Biomedical Engineering, School of Engineering, Brown University, Providence, RI, United States.
Fabiola MunarinCenter for Biomedical Engineering, School of Engineering, Brown University, Providence, RI, United States.
Brown University · USUniversity of Pavia · ITIstituti Clinici Scientifici Maugeri · IT

Funding

Engineering Human Myocardium with Hybrid Biomaterials for Heart Regeneration - SUPPR01HL135091 · NHLBI · BROWN UNIVERSITY · PI COULOMBE, KAREEN LK · 2017 to 2021
$2.6M
NHLBI NIH HHS R01 HL135091
6 · The paper itself

Abstract

Coronary artery disease is a severe ischemic condition characterized by the reduction of blood flow in the arteries of the heart that results in the dysfunction and death of cardiac tissue. Despite research over several decades on how to reduce long-term complications and promote angiogenesis in the infarct, the medical field has yet to define effective treatments for inducing revascularization in the ischemic tissue. With this work, we have developed functional biomaterials for the controlled release of immunomodulatory cytokines to direct immune cell fate for controlling wound healing in the ischemic myocardium. The reparative effects of colony-stimulating factor (CSF-1), and anti-inflammatory interleukins 4/6/13 (IL4/6/13) have been evaluated

Indexed as

angiogenesisbiomaterialscytokinesimmune engineeringmacrophagesmyocardial infarctrevascularization

Identifiers

PMID32318563
PMCPMC7154131
OpenAlexW3016039176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.