Evidence map›Paper›PMID 32318239›Full record

ArticleOxidative medicine and cellular longevity2020

The Role of DNMT and HDACs in the Fetal Programming of Hypertension by Glucocorticoids.

J Lamothe, S Khurana, S Tharmalingam, C Williamson, C J Byrne, N Khaper, S Mercier, T C Tai

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Prenatal dexamethasone programs autonomic dysregulation in female rats.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Development and function of the fetal adrenal.Reviews in endocrine & metabolic disorders · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

J LamotheBiomolecular Sciences, Laurentian University, Sudbury, ON, Canada.
S KhuranaMedical Science Division, Northern Ontario School of Medicine Sudbury, ON, Canada.ORCID https://orcid.org/0000-0002-3263-9840
S TharmalingamMedical Science Division, Northern Ontario School of Medicine Sudbury, ON, Canada.
C WilliamsonBiology, Laurentian University, Sudbury, ON, Canada.
C J ByrneBiology, Laurentian University, Sudbury, ON, Canada.
N KhaperMedical Science Division, Northern Ontario School of Medicine Thunder Bay, ON, Canada.ORCID https://orcid.org/0000-0002-2467-3766
S MercierSchool of Human Kinetics, Laurentian University, Sudbury, ON, Canada.
T C TaiBiomolecular Sciences, Laurentian University, Sudbury, ON, Canada.ORCID https://orcid.org/0000-0001-7581-4234
Laurentian University · CANOSM University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The causes of hypertension are complex and involve both genetic and environmental factors. Environment changes during fetal development have been linked to adult diseases including hypertension. Studies show that timed in utero exposure to the synthetic glucocorticoid (GC) dexamethasone (Dex) results in the development of hypertension in adult rats. Evidence suggests that

Indexed as

AnimalsBlood PressureDecitabineDexamethasoneDNA (Cytosine-5-)-MethyltransferasesEpigenesis, GeneticEpinephrineFemaleGene Expression Regulation, DevelopmentalHistone Deacetylase InhibitorsHistone DeacetylasesHypertensionMalePhenylethanolamine N-MethyltransferasePregnancyPrenatal Exposure Delayed EffectsDecitabineDexamethasoneDNA (Cytosine-5-)-MethyltransferasesEpinephrineHistone Deacetylase InhibitorsHistone DeacetylasesPhenylethanolamine N-MethyltransferaseValproic Acid

Identifiers

PMID32318239
PMCPMC7149440
OpenAlexW3014985699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.