Evidence map›Paper›PMID 32318119›Full record

ArticleBeilstein journal of organic chemistry2020

Design and synthesis of diazine-based panobinostat analogues for HDAC8 inhibition.

Sivaraman Balasubramaniam, Sajith Vijayan, Liam V Goldman, Xavier A May, Kyra Dodson, Sweta Adhikari, Fatima Rivas, Davita L Watkins, Shana V Stoddard

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Beilstein journal of organic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sivaraman BalasubramaniamDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS 38677-1848, USA.
Sajith VijayanDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS 38677-1848, USA.
Liam V GoldmanDepartment of Chemistry, Rhodes College, Memphis, TN 38112, USA.
Xavier A MayDepartment of Chemistry, Rhodes College, Memphis, TN 38112, USA.
Kyra DodsonDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS 38677-1848, USA.
Sweta AdhikariDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS 38677-1848, USA.
Fatima RivasDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105-3678, USA.
Davita L WatkinsDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS 38677-1848, USA.ORCID https://orcid.org/0000-0002-0943-7220
Shana V StoddardDepartment of Chemistry, Rhodes College, Memphis, TN 38112, USA.ORCID https://orcid.org/0000-0002-0721-084X
University of Mississippi · USRhodes College · USSt. Jude Children's Research Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Guided by computational analysis, herein we report the design, synthesis and evaluation of four novel diazine-based histone deacetylase inhibitors (HDACis). The targets of interest (TOI) are analogues of panobinostat, one of the most potent and versatile HDACi reported. By simply replacing the phenyl core of panobinostat with that of a diazine derivative, docking studies against HDAC2 and HDAC8 revealed that the four analogues exhibit inhibition activities comparable to that of panobinostat. Multistep syntheses afforded the visualized targets

Indexed as

diazinehistone deacetylaseinhibitorsisozymespanobinostat

Identifiers

PMID32318119
PMCPMC7155894
OpenAlexW3015881643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.