Evidence map›Paper›PMID 32318063›Full record

ArticleFrontiers in immunology2020

Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis.

Xiaoxiao Lu, Abirami Kugadas, Kirsten Smith-Page, Jeffrey Lamb, Tiffany Lin, Yusha Ru, Sharon Celeste Morley, Raina Fichorova, Sharad K Mittal, Sunil K Chauhan and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Neutrophils in Ocular Diseases.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Conjunctival Commensal Isolation and Identification in Mice.Journal of visualized experiments : JoVE · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Xiaoxiao LuDivision of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Abirami KugadasDivision of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Kirsten Smith-PageDivision of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Jeffrey LambDivision of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Tiffany LinDivision of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Yusha RuDivision of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Sharon Celeste MorleyWashington University School of Medicine, St. Louis, MO, United States.
Raina FichorovaLaboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, MA, United States.
Sharad K MittalSchepens Eye Research Institute, Massachusetts Eye & Ear Infirmary and Harvard Medical School, Boston, MA, United States.
Sunil K ChauhanSchepens Eye Research Institute, Massachusetts Eye & Ear Infirmary and Harvard Medical School, Boston, MA, United States.
Sejiro LittletonDuke Department of Ophthalmology, Duke Eye Center, Durham, NC, United States.
Daniel SabanDuke Department of Ophthalmology, Duke Eye Center, Durham, NC, United States.
Mihaela GadjevaDivision of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Harvard University · USBrigham and Women's Hospital · USSmith-Kettlewell Eye Research Institute · USWashington University in St. Louis · US

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Vadim Y Arshavsky · 1985 to 2026
$19.3M
Defining the Immune Cell Roles in Meibomian Gland Dysfunction in the Context of Ocular Surface Immune DiseasesR01EY021798 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI SABAN, DANIEL RAPHAEL · 2012 to 2025
$5.3M
Contribution of Mast Cells in Non-Allergic Ocular InflammationR01EY029727 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Sunil K Chauhan · 2019 to 2026
$4.2M
Novel treatment strategies to regulate inflammation during P.aeruginosa keratitisR01EY022054 · NEI · BRIGHAM AND WOMEN'S HOSPITAL · PI GADJEVA, MIHAELA GUEORGUIEVA · 2012 to 2020
$4.0M
CONTROL OF ADAPTIVE IMMUNITY BY ACTIN-REGULATORY PROTEINSR01AI104732 · NIAID · WASHINGTON UNIVERSITY · PI MORLEY, SHARON CELESTE · 2014 to 2018
$1.9M
NEI NIH HHS P30 EY005722NEI NIH HHS R01 EY021798NEI NIH HHS R01 EY022054NEI NIH HHS R01 EY029727NIAID NIH HHS R01 AI104732
6 · The paper itself

Abstract

Why ocular mucosa is paucibacterial is unknown. Many different mechanisms have been suggested but the comprehensive experimental studies are sparse. We found that a deficiency in L-plastin (LCP1), an actin bundling protein, resulted in an ocular commensal overgrowth, characterized with increased presence of conjunctival

Indexed as

AnimalsEyeFemaleKeratitisMaleMiceMice, KnockoutMicrofilament ProteinsNeutrophilsLcp1 protein, mouseMicrofilament ProteinscommensalsinfectionkeratritismacrophagesneutrophilsP. aeruginosa

Identifiers

PMID32318063
PMCPMC7147296
OpenAlexW3014807934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.