Evidence map›Paper›PMID 32318015›Full record

ArticleFrontiers in neurology2020

Peak Width of Skeletonized Water Diffusion MRI in the Neonatal Brain.

Manuel Blesa, Paola Galdi, Gemma Sullivan, Emily N Wheater, David Q Stoye, Gillian J Lamb, Alan J Quigley, Michael J Thrippleton, Mark E Bastin, James P Boardman

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Manuel BlesaMRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom.
Paola GaldiMRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom.
Gemma SullivanMRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom.
Emily N WheaterMRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom.
David Q StoyeMRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom.
Gillian J LambMRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom.
Alan J QuigleyDepartment of Radiology, Royal Hospital for Sick Children, Edinburgh, United Kingdom.
Michael J ThrippletonCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Mark E BastinCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
James P BoardmanMRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom.
University of Edinburgh · GBMRC Centre for Reproductive Health · GBRoyal Hospital for Children · GB

Funding

Medical Research Council G1002033Medical Research Council MR/N022556/1The Dunhill Medical Trust R380R/1114Wellcome Trust
6 · The paper itself

Abstract

Preterm birth is closely associated with cognitive impairment and generalized dysconnectivity of neural networks inferred from water diffusion MRI (dMRI) metrics. Peak width of skeletonized mean diffusivity (PSMD) is a metric derived from histogram analysis of mean diffusivity across the white matter skeleton, and it is a useful biomarker of generalized dysconnectivity and cognition in adulthood. We calculated PSMD and five other histogram based metrics derived from diffusion tensor imaging (DTI) and neurite orientation and dispersion imaging (NODDI) in the newborn, and evaluated their accuracy as biomarkers of microstructural brain white matter alterations associated with preterm birth. One hundred and thirty five neonates (76 preterm, 59 term) underwent 3T MRI at term equivalent age. There were group differences in peak width of skeletonized mean, axial, and radial diffusivities (PSMD, PSAD, PSRD), orientation dispersion index (PSODI) and neurite dispersion index (PSNDI), all

Indexed as

diffusion MRIDTIneonateNODDIpretermPSMD

Identifiers

PMID32318015
PMCPMC7146826
OpenAlexW3014334446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.