Evidence map›Paper›PMID 32317975›Full record

ReviewFrontiers in pharmacology2020

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety.

Abdullah Shaito, Duong Thi Bich Thuan, Hoa Thi Phu, Thi Hieu Dung Nguyen, Hiba Hasan, Sarah Halabi, Samar Abdelhady, Gheyath K Nasrallah, Ali H Eid, Gianfranco Pintus

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 193 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
193citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

193 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Biological Mechanisms of Polyphenols againstInfectious disorders drug targets · 2025
    Pooled it
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  7. Oxidative medicine and cellular longevity · 2021
    Pooled it
  8. Article
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  10. Chemical Profiling ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
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  12. Review
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133 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abdullah ShaitoDepartment of Biological and Chemical Sciences, Lebanese International University, Beirut, Lebanon.
Duong Thi Bich ThuanDepartment of Biochemistry, University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.
Hoa Thi PhuDepartment of Biochemistry, University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.
Thi Hieu Dung NguyenDepartment of Physiology, University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.
Hiba HasanInstitute of Anatomy and Cell Biology, Justus Liebig University Giessen, Giessen, Germany.
Sarah HalabiBiology Department, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon.
Samar AbdelhadyFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Gheyath K NasrallahDepartment of Biomedical Sciences, College of Health Sciences, Qatar University, Doha, Qatar.
Ali H EidDepartment of Biomedical Sciences, College of Health Sciences, Qatar University, Doha, Qatar.
Gianfranco PintusDepartment of Medical Laboratory Sciences, University of Sharjah, Sharjah, United Arab Emirates.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular diseases (CVDs) are a significant health burden with an ever-increasing prevalence. They remain the leading causes of morbidity and mortality worldwide. The use of medicinal herbs continues to be an alternative treatment approach for several diseases including CVDs. Currently, there is an unprecedented drive for the use of herbal preparations in modern medicinal systems. This drive is powered by several aspects, prime among which are their cost-effective therapeutic promise compared to standard modern therapies and the general belief that they are safe. Nonetheless, the claimed safety of herbal preparations yet remains to be properly tested. Consequently, public awareness should be raised regarding medicinal herbs safety, toxicity, potentially life-threatening adverse effects, and possible herb-drug interactions. Over the years, laboratory data have shown that medicinal herbs may have therapeutic value in CVDs as they can interfere with several CVD risk factors. Accordingly, there have been many attempts to move studies on medicinal herbs from the bench to the bedside, in order to effectively employ herbs in CVD treatments. In this review, we introduce CVDs and their risk factors. Then we overview the use of herbs for disease treatment in general and CVDs in particular. Further, data on the ethnopharmacological therapeutic potentials and medicinal properties against CVDs of four widely used plants, namely

Indexed as

antioxidantsatherosclerosiscardiovascular diseasesherbal medicinehypertensioninflammationmedicinal plantsoxidative stress

Identifiers

PMID32317975
PMCPMC7155419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.