Evidence map›Paper›PMID 32317736›Full record

ReviewMucosal immunology2020

Seasonal and pandemic influenza: 100 years of progress, still much to learn.

Jake Dunning, Ryan S Thwaites, Peter J M Openshaw

Abstract readHistorical ArticleReview
In one paragraph

Review in Mucosal immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Deoxyshikonin Inhibits Influenza A Virus Infection at an Early Stage.International journal of molecular sciences · 2025
    Article
  12. Article
  13. Anti-Viral Activity of Conessine Against Influenza A Virus.International journal of molecular sciences · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Antiviral Activity of Berbamine Against Influenza A Virus Infection.International journal of molecular sciences · 2025
    Article
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jake DunningPublic Health England, England, UK.
Ryan S ThwaitesNational Heart and Lung Institute, Imperial College London, London, UK.
Peter J M OpenshawNational Heart and Lung Institute, Imperial College London, London, UK. p.openshaw@imperial.ac.uk.ORCID http://orcid.org/0000-0002-7220-2555

Funding

Medical Research Council MC_G1001212
6 · The paper itself

Abstract

Influenza viruses are highly transmissible, both within and between host species. The severity of the disease they cause is highly variable, from the mild and inapparent through to the devastating and fatal. The unpredictability of epidemic and pandemic outbreaks is accompanied but the predictability of seasonal disease in wide areas of the Globe, providing an inexorable toll on human health and survival. Although there have been great improvements in understanding influenza viruses and the disease that they cause, our knowledge of the effects they have on the host and the ways that the host immune system responds continues to develop. This review highlights the importance of the mucosa in defence against infection and in understanding the pathogenesis of disease. Although vaccines have been available for many decades, they remain suboptimal in needing constant redesign and in only providing short-term protection. There are real prospects for improvement in treatment and prevention of influenza soon, based on deeper knowledge of how the virus transmits, replicates and triggers immune defences at the mucosal surface.

Indexed as

PandemicsSeasonsAnimalsAntiviral AgentsBacterial InfectionsBetainfluenzavirusCoinfectionComorbidityDisease OutbreaksHistory, 20th CenturyHistory, 21st CenturyHost-Pathogen InteractionsHumansInfluenza A virusInfluenza, HumanInfluenza VaccinesAntiviral AgentsInfluenza Vaccines

Identifiers

PMID32317736
PMCPMC7223327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.