ArticleScientific reports2020
Control of cell colony growth by contact inhibition.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Equations describing semi-confluent cell growth (II) colony formation on a flat surface.European biophysics journal : EBJ · 2025Article
- Exploring the effects of roscovitine, serum starvation, and contact inhibition at GIn vitro cellular & developmental biology. Animal · 2025Article
- Migrating mesoderm cells self-organize into a dynamic meshwork structure during chick gastrulation.eLife · 2025Article
- Process intensification of cultivated meat production through microcarrier addition strategy optimisation.Scientific reports · 2025Article
- Same same but different? How blood and lymphatic vessels induce cell contact inhibition.Biochemical Society transactions · 2025Review
- The preparation methods and types of cell sheets engineering.Stem cell research & therapy · 2024Review
- Mechanical control of cell proliferation patterns in growing epithelial monolayers.Biophysical journal · 2024Article
- Integrated Experimental and Mathematical Exploration of Modular Tissue Cultures for Developmental Engineering.International journal of molecular sciences · 2024Article
- Mechanical control of cell proliferation patterns in growing tissues.bioRxiv : the preprint server for biology · 2023Article
- Hepatic Spheroid Formation on Carbohydrate-Functionalized Supramolecular Hydrogels.Biomacromolecules · 2023Article
- Engineering strategies and optimized delivery of exosomes for theranostic application in nerve tissue.Theranostics · 2023Review
- MACC1-Induced Collective Migration Is Promoted by Proliferation Rather Than Single Cell Biomechanics.Cancers · 2022Article
- A computational model of organism development and carcinogenesis resulting from cells' bioelectric properties and communication.Scientific reports · 2022Article
- Disentangling cadherin-mediated cell-cell interactions in collective cancer cell migration.Biophysical journal · 2022Article
- Brick Strex: a robust device built of LEGO bricks for mechanical manipulation of cells.Scientific reports · 2021Article
- Size-dependent patterns of cell proliferation and migration in freely-expanding epithelia.eLife · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contact inhibition is a cell property that limits the migration and proliferation of cells in crowded environments. Here we investigate the growth dynamics of a cell colony composed of migrating and proliferating cells on a substrate using a minimal model that incorporates the mechanisms of contact inhibition of locomotion and proliferation. We find two distinct regimes. At early times, when contact inhibition is weak, the colony grows exponentially in time, fully characterised by the proliferation rate. At long times, the colony boundary moves at a constant speed, determined only by the migration speed of a single cell and independent of the proliferation rate. Further, the model demonstrates how cell-cell alignment speeds up colony growth. Our model illuminates how simple local mechanical interactions give rise to contact inhibition, and from this, how cell colony growth is self-organised and controlled on a local level.
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