ArticleScientific reports2020
Unravelling the consequences of the bacteriophages in human samples.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Potential of phage therapy for the treatment of diabetic foot infections.Folia microbiologica · 2026Review
- Bacteriophage inactivation to prevent carry-over in preclinical assays with mycobacteria.Research square · 2026Article
- Identification of bacteriophage DNA in human umbilical cord blood.JCI insight · 2025Article
- Dual Nature of Bacteriophages: Friends or Foes in Minimally Processed Food Products-A Comprehensive Review.Viruses · 2025Review
- The virome composition of respiratory tract changes in school-aged children with Mycoplasma pneumoniae infection.Virology journal · 2025Article
- The cerebrospinal fluid virome in people with HIV: links to neuroinflammation and cognition.Frontiers in microbiology · 2025Article
- Recruitment of complete crAss-like phage genomes reveals their presence in chicken viromes, few human-specific phages, and lack of universal detection.The ISME journal · 2024Article
- Phage therapy for extensively drug resistantFrontiers in medicine · 2024Article
- InducedFrontiers in microbiology · 2024Article
- Development of a Replication-Deficient Bacteriophage Reporter Lacking an Essential Baseplate Wedge Subunit.Viruses · 2023Article
- Article
- Dominance of phage particles carrying antibiotic resistance genes in the viromes of retail food sources.The ISME journal · 2023Article
- The Safety and Efficacy of Phage Therapy: A Systematic Review of Clinical and Safety Trials.Antibiotics (Basel, Switzerland) · 2022Review
- Chicken liver is a potential reservoir of bacteriophages and phage-derived particles containing antibiotic resistance genes.Microbial biotechnology · 2022Article
- Phage therapeutics: from promises to practices and prospectives.Applied microbiology and biotechnology · 2021Review
- Lung microbiome of stable and exacerbated COPD patients in Tshwane, South Africa.Scientific reports · 2021Article
- Interactions of Bacteriophages with Animal and Human Organisms-Safety Issues in the Light of Phage Therapy.International journal of molecular sciences · 2021Review
- Bacteriophages immunomodulate the response of monocytes.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- The Role of Antibiotic ResistantAntibiotics (Basel, Switzerland) · 2021Review
- Phage Prevalence in the Human Urinary Tract-Current Knowledge and Therapeutic Implications.Microorganisms · 2020Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteriophages are abundant in human biomes and therefore in human clinical samples. Although this is usually not considered, they might interfere with the recovery of bacterial pathogens at two levels: 1) by propagating in the enrichment cultures used to isolate the infectious agent, causing the lysis of the bacterial host and 2) by the detection of bacterial genes inside the phage capsids that mislead the presence of the bacterial pathogen. To unravel these interferences, human samples (n = 271) were analyzed and infectious phages were observed in 11% of blood culture, 28% of serum, 45% of ascitic fluid, 14% of cerebrospinal fluid and 23% of urine samples. The genetic content of phage particles from a pool of urine and ascitic fluid samples corresponded to bacteriophages infecting different bacterial genera. In addition, many bacterial genes packaged in the phage capsids, including antibiotic resistance genes and 16S rRNA genes, were detected in the viromes. Phage interference can be minimized applying a simple procedure that reduced the content of phages up to 3 logs while maintaining the bacterial load. This method reduced the detection of phage genes avoiding the interference with molecular detection of bacteria and reduced the phage propagation in the cultures, enhancing the recovery of bacteria up to 6 logs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.