Evidence map›Paper›PMID 32317601›Full record

ArticleCritical care medicine2020

Impact of Bilateral Infiltrates on Inflammatory Biomarker Levels and Clinical Outcomes of Children With Oxygenation Defect.

Joseph G Kohne, Mary K Dahmer, Heidi M Weeks, Niko Kaciroti, Michael W Quasney, Anil Sapru, Martha A Q Curley, Michael Matthay, Heidi Flori

Registry-linked trialOpen access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00814099 (Sedation Management in Pediatric Patients With Acute Respiratory Failure), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00814099 nacompletednot on this map

Sedation Management in Pediatric Patients With Acute Respiratory Failure

TypeinterventionalSponsorUniversity of PennsylvaniaRan2009 to 2013Enrolled2,449ConditionsRespiratory Insufficiency, Respiratory Distress Syndrome, Newborn, Lung DiseasesArmsTeam approach to sedation management, Usual approach to sedation management
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Pathobiology, Severity, and Risk Stratification of Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Joseph G KohneDivision of Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, MI.
Mary K DahmerDivision of Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, MI.
Heidi M WeeksDepartment of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI.
Niko KacirotiCenter for Human Growth and Development, University of Michigan, Ann Arbor, MI.
Michael W QuasneyDivision of Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, MI.
Anil SapruDepartment of Pediatrics, University of California, Los Angeles, CA.
Martha A Q CurleyDivision of Anesthesia and Critical Care Medicine, Department of Family and Community Health (School of Nursing), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Michael MatthayDepartment of Medicine, Cardiovascular Research Institute, University of California, San Francisco, CA.
Heidi FloriDivision of Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, MI.
University of Michigan–Ann Arbor · USChildren's Hospital of Philadelphia · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · US

Funding

Sedation Management in Pediatric Patients with Acute Respiratory FailureU01HL086622 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CURLEY, MARTHA AQ · 2008 to 2013
$10.0M
Sedation Management in Pediatric Patients with Acute Respiratory Failure (DCC)U01HL086649 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI WYPIJ, DAVID · 2008 to 2012
$2.0M
Genetic variation and biomarkers in children with acute lung injuryR01HL095410 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAHMER, MARY K, FLORI, HEIDI R · 2009 to 2012
$1.8M
NHLBI NIH HHS R01 HL095410NHLBI NIH HHS U01 HL086622NHLBI NIH HHS U01 HL086649
6 · The paper itself

Abstract

objectivesThe 2015 definition for pediatric acute respiratory distress syndrome did not require the presence of bilateral infiltrates. We tested the hypothesis that pediatric patients meeting oxygenation criteria for pediatric acute respiratory distress syndrome but without bilateral infiltrates would have different inflammatory biomarker levels and clinical outcomes than those with bilateral infiltrates.

designSecondary analysis of a prospective cohort study.

settingTwenty-two PICUs. PATIENTS: Four-hundred forty-six patients age 2 weeks to 17 years intubated for respiratory failure with oxygenation index greater than or equal to 4 or oxygenation saturation index greater than or equal to 5 on the day of intubation or the day after.

interventionsNone. MEASUREMENTS AND MAIN

resultsPatients with bilateral infiltrates, either on the day of intubation or within the following 2 days, were compared with children who never developed bilateral infiltrates. Two analyses were performed to test 1) whether bilateral infiltrates are associated with elevated interleukin-1 receptor antagonist or interleukin-8 and 2) whether bilateral infiltrates are associated with worse clinical outcomes. Patients with bilateral infiltrates more often had a primary diagnosis of pneumonia (41% vs 28%; p = 0.02) and less often asthma (8% vs 23%; p < 0.01). After controlling for age, gender, and primary diagnosis, interleukin-1 receptor antagonist was higher on study days 1 and 2 in patients with bilateral infiltrates. There was no difference in interleukin-8 levels. After adjusting for age, gender, Pediatric Risk of Mortality score, and severity of oxygenation defect, presence of bilateral infiltrates was associated with longer duration of mechanical ventilation in survivors (hazard ratio, 0.64; 95% CI, 0.49-0.82; p < 0.01); this association was independent of primary diagnosis. Overall mortality was 9%; mortality was higher in those without bilateral infiltrates (14% vs 8%; p = 0.04).

conclusionsChildren meeting pediatric acute respiratory distress syndrome oxygenation criteria with bilateral infiltrates on chest radiograph experience a more intense early inflammatory response. Bilateral infiltrates are associated with longer time on the ventilator independent of oxygenation defect severity.

Indexed as

AdolescentAsthmaBiomarkersChildChild, PreschoolFemaleHumansInfantInfant, NewbornInflammation MediatorsIntensive Care Units, PediatricInterleukin-8Intubation, IntratrachealMaleProspective StudiesReceptors, Interleukin-1BiomarkersInflammation MediatorsInterleukin-8Receptors, Interleukin-1

Identifiers

PMID32317601
PMCPMC10910885
OpenAlexW3016920386

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.