ArticleCritical care medicine2020
Association of Hypoactive and Hyperactive Delirium With Cognitive Function After Critical Illness.
Article in Critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Exercise therapy for the treatment of delirium in the intensive care unit.The Cochrane database of systematic reviews · 2025Pooled it
- Non-pharmacological interventions for delirium in the pediatric population: a systematic review with narrative synthesis.BMC pediatrics · 2024Pooled it
- How do predisposing factors differ between delirium motor subtypes? A systematic review and meta-analysis.Age and ageing · 2022Pooled it
- Effects of narrative nursing on delirium and outcomes in mechanically ventilated ICU patients: a randomized trial.Trials · 2025Trial
- A randomized pilot and feasibility trial of live and recorded music interventions for management of delirium symptoms in acute geriatric patients.BMC geriatrics · 2025Trial
- The 2026 World Delirium Awareness Day Survey: Findings From Turkish Intensive Care Units.Nursing in critical care · 2026Article
- Delirium Among Adults Undergoing Transcatheter Structural Heart Intervention: Incidence, Risk, and Clinical Phenotypes.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- Prophylactic Olanzapine Versus Placebo in Comatose Survivors of Out-of-Hospital Cardiac Arrest: Protocol for a Multicenter Randomized Comparison Within the Danish Out-of-Hospital Cardiac Arrest (DANOHCA) Trial.Acta anaesthesiologica Scandinavica · 2026Article
- Substance Use and Delirium Trends in the Critically Ill During the Peri-COVID Period.Critical care explorations · 2026Article
- Clinician knowledge, attitudes, and perceptions of delirium in patients with grade 3 bronchopulmonary dysplasia: A national survey.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Research progress in agitation early warning monitoring and new technologies for critically ill patients: a narrative review.Frontiers in medicine · 2026Review
- Delirium Management in Critical Care: Are We Moving Forward or Still Treading Water?Medical sciences (Basel, Switzerland) · 2025Review
- Clinical Nursing Management of Adult Patients with Delirium in a Hospital Setting-A Systematic Review.Journal of clinical medicine · 2025Review
- Translation, Adaptation, and Criterion Validation of the Family Caregiver Assessment Tool for French-Speaking Cardiovascular Patients in Canada (FAM-CAM-Fr).The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres · 2025Article
- The Association Between Frequency of Fingertip Blood Glucose Measurement and Delirium in Intensive Care Unit Patients: A Retrospective Study Based on the MIMIC-IV Database.Nursing in critical care · 2025Article
- Article
- Multidimensional Radiological Assessment of Delirium in the Emergency Department.Healthcare (Basel, Switzerland) · 2025Article
- Evaluating the Effectiveness of Educational Intervention on ICU Nurses' Knowledge of Delirium: A Quasi-Experimental Approach.Nursing reports (Pavia, Italy) · 2025Article
- Survivorship After Cardiogenic Shock.Circulation · 2025Review
- Development and internal verification of nomogram for forecasting delirium in the elderly admitted to intensive care units: an analysis of MIMIC-IV database.Frontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesDelirium, a heterogenous syndrome, is associated with worse long-term cognition after critical illness. We sought to determine if duration of motoric subtypes of delirium are associated with worse cognition.
designSecondary analysis of prospective multicenter cohort study.
settingAcademic, community, and Veteran Affairs hospitals. PATIENTS: Five-hundred eighty-two survivors of respiratory failure or shock.
interventionsWe assessed delirium and level of consciousness using the Confusion Assessment Method-ICU and Richmond Agitation Sedation Scale daily during hospitalization. We defined a day with hypoactive delirium as a day with positive Confusion Assessment Method-ICU and corresponding Richmond Agitation Sedation Scale score less than or equal to 0 and a day with hyperactive delirium as a day with positive Confusion Assessment Method-ICU and corresponding Richmond Agitation Sedation Scale score greater than 0. At 3 and 12 months, we assessed global cognition with the Repeatable Battery for the Assessment of Neurologic Status and executive function with the Trail Making Test Part B. We used multivariable regression to examine the associations between days of hypoactive and hyperactive delirium with cognition outcomes. We allowed for interaction between days of hypoactive and hyperactive delirium and adjusted for baseline and in-hospital covariates. MEASUREMENTS AND
resultsHypoactive delirium was more common and persistent than hyperactive delirium (71% vs 17%; median 3 vs 1 d). Longer duration of hypoactive delirium was associated with worse global cognition at 3 (-5.13 [-8.75 to -1.51]; p = 0.03) but not 12 (-5.76 [-9.99 to -1.53]; p = 0.08) months and with worse executive functioning at 3 (-3.61 [-7.48 to 0.26]; p = 0.03) and 12 (-6.22 [-10.12 to -2.33]; p = 0.004) months; these associations were not modified by hyperactive delirium. Hyperactive delirium was not associated with global cognition or executive function in this cohort.
conclusionsLonger duration of hypoactive delirium was independently associated with worse long-term cognition. Assessing motoric subtypes of delirium in the ICU might aid in prognosis and intervention allocation. Future studies should consider delineating motoric subtypes of delirium.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.