Evidence map›Paper›PMID 32317394›Full record

ArticleJournal of cell science2020

Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia.

Karolina Losenkova, Mariachiara Zuccarini, Marika Karikoski, Juha Laurila, Detlev Boison, Sirpa Jalkanen, Gennady G Yegutkin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 37 citations in OpenAlex.

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  15. Purinergic Signaling in Oral Tissues.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Karolina LosenkovaMediCity Research Laboratory, University of Turku, 20520 Turku, Finland.ORCID 0000-0001-5396-7555
Mariachiara ZuccariniMediCity Research Laboratory, University of Turku, 20520 Turku, Finland.ORCID 0000-0001-8485-9012
Marika KarikoskiMediCity Research Laboratory, University of Turku, 20520 Turku, Finland.
Juha LaurilaMediCity Research Laboratory, University of Turku, 20520 Turku, Finland.
Detlev BoisonDepartment of Neurosurgery, Robert Wood Johnson and New Jersey Medical Schools, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0002-7740-5781
Sirpa JalkanenMediCity Research Laboratory, University of Turku, 20520 Turku, Finland.ORCID 0000-0002-1922-9732
Gennady G YegutkinMediCity Research Laboratory, University of Turku, 20520 Turku, Finland genyeg@utu.fi.ORCID 0000-0001-6684-7982
University of Turku · FIRutgers, The State University of New Jersey · US

Funding

The Role of Adenosine in Ketogenic Diet TherapyR01NS065957 · NINDS · TRINITY COLLEGE · PI BOISON, DETLEV, GEIGER, JONATHAN DAVID · 2010 to 2021
$3.9M
Adenosine receptor mediated therapies for SUDEPR01NS103740 · NINDS · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI BOISON, DETLEV · 2018 to 2022
$1.7M
NINDS NIH HHS R01 NS065957NINDS NIH HHS R01 NS103740
6 · The paper itself

Abstract

Extracellular adenosine mediates diverse anti-inflammatory, angiogenic and vasoactive effects, and has become an important therapeutic target for cancer, which has been translated into clinical trials. This study was designed to comprehensively assess adenosine metabolism in prostate and breast cancer cells. We identified cellular adenosine turnover as a complex cascade, comprising (1) the ectoenzymatic breakdown of ATP via sequential ecto-nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1, officially known as ENPP1), ecto-5'-nucleotidase (CD73, also known as NT5E), and adenosine deaminase reactions, and ATP re-synthesis through a counteracting adenylate kinase and members of the nucleoside diphosphate kinase (NDPK, also known as NME/NM23) family; (2) the uptake of nucleotide-derived adenosine via equilibrative nucleoside transporters; and (3) the intracellular adenosine phosphorylation into ATP by adenosine kinase and other nucleotide kinases. The exposure of cancer cells to 1% O

Indexed as

Adenosine TriphosphateNeoplasmsAdenosineAdenosine DiphosphateAdenylate KinaseAnimalsHypoxiaMaleMiceNucleotidesAdenosineAdenosine DiphosphateAdenosine TriphosphateAdenylate KinaseNucleotidesAdenosine kinaseAdenosine metabolismBreast tumor xenograftCancer cellsCD39CD73Ecto-5′-nucleotidaseHypoxia

Identifiers

PMID32317394
PMCPMC10681022
OpenAlexW3016534231

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.