ArticleScience signaling2020
Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity.
Open access · greenAbstract read
In one paragraph
Article in Science signaling, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
What it found
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Stay in touch with the endoplasmic reticulum.Science China. Life sciences · 2024Pooled it
- Prohibitin controls MRS2-Mediated mitochondrial MgCell reports · 2026Article
- The pyruvate transporter hermes regulates autophagy and health by modulating ROS production.Cell reports · 2026Article
- Restoration of mitochondrial CaJournal of molecular and cellular cardiology · 2026Article
- Advances in understanding mitophagy's role in lung injury.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026Review
- Calcium imbalance drives organelle network collapse and immune remodeling: novel pathogenic mechanisms in MASLD progression.Frontiers in immunology · 2026Review
- Bioinformatics and machine learning approaches to explore the biomarkers in fatty acid degradation linked to osteoarthritis.Frontiers in immunology · 2026Article
- Mitochondrial CaJournal of cellular physiology · 2025Review
- Improving effect of physical exercise on heart failure: Reducing oxidative stress-induced inflammation by restoring CaMolecular and cellular biochemistry · 2025Review
- Exploring the interplay between mitochondria and endoplasmic reticulum in pulmonary arterial hypertension.Frontiers in cardiovascular medicine · 2025Review
- Calcium signaling in mitochondrial intermembrane space.Biochemical Society transactions · 2024Review
- Mitochondrial Calcium Regulation of Cardiac Metabolism in Health and Disease.Physiology (Bethesda, Md.) · 2024Review
- MICU1's calcium sensing beyond mitochondrial calcium uptake.Biochimica et biophysica acta. Molecular cell research · 2024Review
- Mrs2-mediated mitochondrial magnesium uptake is essential for the regulation of MCU-mediated mitochondrial CaMitochondrion · 2024Article
- Chrysin Inhibits TAMs-Mediated Autophagy Activation via CDK1/ULK1 Pathway and Reverses TAMs-Mediated Growth-Promoting Effects in Non-Small Cell Lung Cancer.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Chronic exercise improves hepatic acylcarnitine handling.iScience · 2024Article
- Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast-twitch muscle in rats.Physiological reports · 2024Article
- Sensitive monitoring of NAD(P)H levels within cancer cells using mitochondria-targeted near-infrared cyanine dyes with optimized electron-withdrawing acceptors.Journal of materials chemistry. B · 2024Article
- AnPlant signaling & behavior · 2023Article
- Isogenic pairs of induced-pluripotent stem-derived endothelial cells identify DYRK1A/PPARG/EGR1 pathway is responsible for Down syndrome-associated pulmonary hypertension.Human molecular genetics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 4 institutions in 1 country.
Neeharika NemaniDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.ORCID 0000-0002-2012-4639
Zhiwei DongDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Cassidy C DawDepartment of Medicine/Nephrology Division, Center for Precision Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0002-3441-0425
Travis R MadarisDepartment of Medicine/Nephrology Division, Center for Precision Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0002-0182-1949
Karthik RamachandranDepartment of Medicine/Nephrology Division, Center for Precision Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0003-3673-3559
Benjamin T EnslowDepartment of Medicine/Nephrology Division, Center for Precision Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0003-4822-0216
Cherubina S RubannelsonkumarDepartment of Medicine/Nephrology Division, Center for Precision Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0002-8448-0827
Santhanam ShanmughapriyaDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.ORCID 0000-0003-1041-8198
Varshini MallireddigariDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.ORCID 0000-0002-8849-5954
Soumya MaityDepartment of Medicine/Nephrology Division, Center for Precision Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Pragya SinghMallaDepartment of Medicine/Nephrology Division, Center for Precision Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Kalimuthusamy NatarajanseenivasanDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Robert HooperFels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA 19140, USA.
Christopher E ShannonDepartment of Medicine/Diabetes Division, University of Texas Health San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0003-0240-0609
Warren G TourtellottePathology & Laboratory Medicine, Neurology, Neurosurgery, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Brij B SinghDepartment of Periodontics, University of Texas Health San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0003-0535-5997
W Brian ReevesDepartment of Medicine/Nephrology Division, Center for Precision Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0001-5191-5866
Kumar SharmaDepartment of Medicine/Nephrology Division, Center for Precision Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0002-7550-8525
Luke NortonDepartment of Medicine/Diabetes Division, University of Texas Health San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0002-0231-5722
Subramanya SrikantanDepartment of Medicine/Nephrology Division, Center for Precision Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0003-1810-6519
Jonathan SoboloffDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.ORCID 0000-0001-5192-1297
Muniswamy MadeshDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA. muniswamy@uthscsa.edu.ORCID 0000-0001-6745-9092
The University of Texas Health Science Center at San Antonio · USTemple University · USCedars-Sinai Medical Center · USPenn State Milton S. Hershey Medical Center · US
Funding
San Antonio Biomedical Education and ResearchK12GM111726 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LECHLEITER, JAMES D, OYAJOBI, BABATUNDE OLUKAYODE · 2015 to 2024
$7.6MCoordination of Pathophysiologic Endothelial Cell Signaling by ROSR01HL086699 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2008 to 2018
$4.3MSpectral revelations of mitochondrial Ca2+ flux interactomeR01GM109882 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2014 to 2022
$3.3MGENE EXPRESSION AND CONTENT IN CELL DIFFERENTIATIONR01GM011726 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ATTARDI, GIUSEPPE · 1985 to 2006
$3.0MMOLECULAR MECHANISMS MEDIATING NERVE-MUSCLE INTERACTIONSR01NS040748 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI TOURTELLOTTE, WARREN G · 2001 to 2010
$2.7MControl of Endothelial Mechanotransduction by the Mitochondrial Ca2+ Uniporter: Implications for AtherosclerosisR01HL142673 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ALEVRIADOU, BARBARA RITA, MUNISWAMY, MADESH · 2018 to 2021
$2.0MDefining STIM1 function at the Immunological SynapseR01AI152506 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI SOBOLOFF, JONATHAN A · 2020 to 2024
$2.0MNRSA Training Core (TL1)TL1TR002647 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CHUN, YONG-HEE PATRICIA, FREI, CHRISTOPHER R. · 2018 to 2022
$1.8MTRPM2 in Ischemic AKIR01DK108185 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI REEVES, WILLIAM BRIAN · 2016 to 2019
$1.7MElp1 function in Familial DysautonomiaR01NS095894 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI TOURTELLOTTE, WARREN G · 2016 to 2019
$1.6MEGR-mediated STIM1-PMCA expression and function in T cell subsetsR01GM117907 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI SOBOLOFF, JONATHAN A · 2016 to 2019
$1.6MIMMEDIATE EARLY GENE REGULATED DEVELOPMENT/PLASTICITYK02NS046468 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI TOURTELLOTTE, WARREN G · 2005 to 2009
$785kNCATS NIH HHS TL1 TR002647NCRR NIH HHS K26 RR026099NCRR NIH HHS S10 RR027327NHLBI NIH HHS K99 HL138268NHLBI NIH HHS R00 HL138268NHLBI NIH HHS R01 HL086699NHLBI NIH HHS R01 HL142673NIAID NIH HHS R01 AI152506NIAID NIH HHS T32 AI138944NIDDK NIH HHS R01 DK108185NIGMS NIH HHS K12 GM111726NIGMS NIH HHS R01 GM011726NIGMS NIH HHS R01 GM109882NIGMS NIH HHS R01 GM117907NIH HHS K26 OD010945NINDS NIH HHS K02 NS046468NINDS NIH HHS R01 NS040748NINDS NIH HHS R01 NS095894
Abstract
The tricarboxylic acid (TCA) cycle converts the end products of glycolysis and fatty acid β-oxidation into the reducing equivalents NADH and FADH
Indexed as
AnimalsBiological Transport, ActiveCalcium-Binding ProteinsCalcium ChannelsCation Transport ProteinsFatty AcidsHEK293 CellsHeLa CellsHep G2 CellsHumansMice, KnockoutMitochondria, LiverMitochondrial Membrane Transport ProteinsMitochondrial ProteinsPyruvic AcidCalcium-Binding ProteinsCalcium ChannelsCation Transport ProteinsFatty AcidsMcu protein, mouseMICU1 protein, humanMICU1 protein, mouseMitochondrial Membrane Transport ProteinsMitochondrial ProteinsPyruvic Acid
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.