ArticleActa neuropathologica communications2020
Hippocampal granule cell dispersion: a non-specific finding in pediatric patients with no history of seizures.
Article in Acta neuropathologica communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Focal granule cell bilamination of the dentate gyrus-its prevalence across the human age spectrum and review of the literature.Journal of neuropathology and experimental neurology · 2025Review
- Developmental mechanisms underlying pediatric epilepsy.Frontiers in neurology · 2025Review
- Raphe and ventrolateral medulla proteomics in sudden unexplained death in childhood with febrile seizure history.Acta neuropathologica · 2024Article
- Inhibition of Granule Cell Dispersion and Seizure Development by Astrocyte Elevated Gene-1 in a Mouse Model of Temporal Lobe Epilepsy.Biomolecules · 2024Article
- Neurodevelopmental disorders: 2023 update.Free neuropathology · 2023Article
- Opioids, microglia, and temporal lobe epilepsy.Frontiers in neurology · 2023Review
- Anti-epileptic Kunitz-like peptides discovered in the branching coral Acropora digitifera through transcriptomic analysis.Archives of toxicology · 2022Article
- Proteomic differences in hippocampus and cortex of sudden unexplained death in childhood.Acta neuropathologica · 2022Article
- Blinded review of hippocampal neuropathology in sudden unexplained death in childhood reveals inconsistent observations and similarities to explained paediatric deaths.Neuropathology and applied neurobiology · 2022Article
- Progression in Time of Dentate Gyrus Granule Cell Layer Widening due to Excitotoxicity Occurs along In Vivo LTP Reinstatement and Contextual Fear Memory Recovery.Neural plasticity · 2022Article
- Tetrodotoxin prevents heat-shock induced granule cell dispersion in hippocampal slice cultures.Frontiers in cell and developmental biology · 2022Article
- Considering the Role of Extracellular Matrix Molecules, in Particular Reelin, in Granule Cell Dispersion Related to Temporal Lobe Epilepsy.Frontiers in cell and developmental biology · 2022Review
- Adult-Onset Neuronal Ceroid Lipofuscinosis With a NovelFrontiers in aging neuroscience · 2022Article
- Non-synaptic Cell-Autonomous Mechanisms Underlie Neuronal Hyperactivity in a Genetic Model ofFrontiers in molecular neuroscience · 2021Article
- Heat-Shock Induces Granule Cell Dispersion and Microgliosis in Hippocampal Slice Cultures.Frontiers in cell and developmental biology · 2021Article
- Neuropathology in the North American sudden unexpected death in epilepsy registry.Brain communications · 2021Article
- Medullary Serotonergic Binding Deficits and Hippocampal Abnormalities in Sudden Infant Death Syndrome: One or Two Entities?Frontiers in pediatrics · 2021Article
- Sudden Unexplained Death in Childhood: A Neuropathology Review.Frontiers in neurology · 2020Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Chronic epilepsy has been associated with hippocampal abnormalities like neuronal loss, gliosis and granule cell dispersion. The granule cell layer of a normal human hippocampal dentate gyrus is traditionally regarded as a compact neuron-dense layer. Histopathological studies of surgically resected or autopsied hippocampal samples primarily from temporal lobe epilepsy patients, as well as animal models of epilepsy, describe variable patterns of granule cell dispersion including focal cell clusters, broader thick segments, and bilamination or "tram-tracking". Although most studies have implicated granule cell dispersion as a specific feature of chronic epilepsy, very few "non-seizure" controls were included in these published investigations. Our retrospective survey of 147 cadaveric pediatric human hippocampi identified identical morphological spectra of granule cell dispersion in both normal and seizure-affected brains. Moreover, sections across the entire antero-posterior axis of a control cadaveric hippocampus revealed repetitive occurrence of different morphologies of the granule cell layer - compact, focally disaggregated and bilaminar. The results indicate that granule cell dispersion is within the spectrum of normal variation and not unique to patients with epilepsy. We speculate that sampling bias has been responsible for an erroneous dogma, which we hope to rectify with this investigation.
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Registered trials
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