Evidence map›Paper›PMID 32317004›Full record

ArticleTrials2020

In response: Letter on update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol.

Christopher J Lindsell, Anna McGlothlin, Samuel Nwosu, Todd W Rice, Alex Hall, Gordon R Bernard, Laurence W Busse, E Wesley Ely, Alpha A Fowler, David F Gaieski and 11 more

Registry-linked trialOpen access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03509350 (A Multi-center, Randomized, Placebo-controlled, Double-blind, Adaptive Clinical Trial of Vitamin C, Thiamine and Steroids as Combination Therapy in Patients With Sepsis.), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03509350 phase3completednot on this map

A Multi-center, Randomized, Placebo-controlled, Double-blind, Adaptive Clinical Trial of Vitamin C, Thiamine and Steroids as Combination Therapy in Patients With Sepsis.

TypeinterventionalSponsorEmory UniversityRan2018 to 2020Enrolled501ConditionsSepsisArmsVitamin C, Thiamine, Hydrocortisone, Vitamin C Placebo, Thiamine Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 11 institutions in 1 country.

Christopher J LindsellDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA. chris.lindsell@vumc.org.
Anna McGlothlinBerry Consultants, LLC, Austin, TX, USA.
Samuel NwosuDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Todd W RiceDivision of Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Alex HallDepartment of Emergency Medicine, Emory University, Atlanta, GA, USA.
Gordon R BernardDivision of Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Laurence W BusseDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA.
E Wesley ElyDivision of Pulmonary & Critical Care, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Alpha A FowlerDivision of Pulmonary Disease & Critical Care Medicine, Department of Internal Medicine, The VCU Johnson Center for Critical Care and Pulmonary Research, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
David F GaieskiDepartment of Emergency Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Jeremiah S HinsonDepartment of Emergency Medicine, Johns Hopkins University, Baltimore, MD, USA.
Michael H HooperDivision of Pulmonary & Critical Care Medicine, Department of Medicine, Eastern Virginia Medical School and Sentara Healthcare, Norfolk, VA, USA.
James C JacksonDivision of Pulmonary & Critical Care, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Gabor D KelenDepartment of Emergency Medicine, Johns Hopkins University, Baltimore, MD, USA.
Mark LevineMolecular & Clinical Nutrition Section, Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD, USA.
Greg S MartinGrady Memorial Hospital, Atlanta, GA, USA.
Richard E RothmanDepartment of Emergency Medicine, Johns Hopkins University, Baltimore, MD, USA.
Jonathan E SevranskyDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, Emory Critical Care Center, Atlanta, GA, USA.
Kert VieleBerry Consultants, LLC, Austin, TX, USA.
David W WrightDepartment of Emergency Medicine, Emory University, Atlanta, GA, USA.
David N HagerDivision of Pulmonary & Critical Care Medicine, Department of Medicine, Johns Hopkins University, 1800 Orleans Street, Suite 9121, Baltimore, MD, 21287, USA.
Johns Hopkins University · USEmory University · USVanderbilt University · USBerry & Associates (United States) · USGrady Memorial Hospital · USVanderbilt University Medical Center · USEastern Virginia Medical School · USGeriatric Research Education and Clinical Center · USNational Institute of Diabetes and Digestive and Kidney Diseases · USThomas Jefferson University · USVirginia Commonwealth University · US

Funding

Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
Ascorbic acid as a pharmacologic agent in disease treatmentZIADK053212 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI LEVINE, MARK A · 2009 to 2025
$8.5M
NCATS NIH HHS UL1 TR002649
6 · The paper itself

Abstract

trial registrationClinicalTrials.gov: NCT03509350. Registered on 26 April 2018.

Indexed as

Anti-Inflammatory AgentsAscorbic AcidDrug Therapy, CombinationHumansHydrocortisoneSepsisThiamineTime-to-TreatmentTreatment OutcomeVitamin B ComplexAnti-Inflammatory AgentsAscorbic AcidHydrocortisoneThiamineVitamin B Complex

Identifiers

PMID32317004
PMCPMC7175511
OpenAlexW3016850443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.