Evidence map›Paper›PMID 32316976›Full record

Trial reportRespiratory research2020

Responsiveness and minimal clinically important difference of SGRQ-I and K-BILD in idiopathic pulmonary fibrosis.

Thomas Skovhus Prior, Nils Hoyer, Ole Hilberg, Saher Burhan Shaker, Jesper Rømhild Davidsen, Elisabeth Bendstrup

Registry-linked trialOpen access · goldAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02818712 (Health-related Quality of Life and Comorbidities in Danish Patients With Idiopathic Pulmonary Fibrosis - a Nationwide Follow-up), which is not on this map. Cited by 26 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 5 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02818712 completednot on this map

Health-related Quality of Life and Comorbidities in Danish Patients With Idiopathic Pulmonary Fibrosis - a Nationwide Follow-up

TypeobservationalSponsorAarhus University HospitalRan2016 to 2021Enrolled150ConditionsIdiopathic Pulmonary Fibrosis
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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  5. Health-related quality of life of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Thomas Skovhus PriorCenter for Rare Lung Diseases, Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200, Aarhus N, Denmark. thbjer@rm.dk.
Nils HoyerDepartment of Respiratory Medicine, Herlev and Gentofte Hospital, Copenhagen, Denmark.
Ole HilbergDepartment of Respiratory Medicine, Vejle Hospital, Vejle, Denmark.
Saher Burhan ShakerDepartment of Respiratory Medicine, Herlev and Gentofte Hospital, Copenhagen, Denmark.
Jesper Rømhild DavidsenDepartment of Respiratory Medicine, Odense University Hospital, Odense, Denmark.
Elisabeth BendstrupCenter for Rare Lung Diseases, Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200, Aarhus N, Denmark.
Aarhus University Hospital · DKGentofte Hospital · DKOdense University Hospital · DKVejle Sygehus · DK

Funding

TrygFonden 118860
6 · The paper itself

Abstract

backgroundIdiopathic pulmonary fibrosis (IPF) specific version of St. George's Respiratory Questionnaire (SGRQ-I) and King's Brief Interstitial Lung Disease questionnaire (K-BILD) are validated health-related quality of life (HRQL) instruments, but no or limited data exist on their responsiveness and minimal clinically important difference (MCID). The objectives of this study were to assess responsiveness of SGRQ-I and K-BILD and determine MCID separately for deterioration and improvement in a large, prospective cohort of patients with IPF in a real-world setting.

methodsConsecutive patients with IPF were recruited. SGRQ-I, K-BILD, SGRQ, Shortness of Breath Questionnaire, pulmonary function tests and 6-min walk test measurements were obtained at baseline and at six and 12 months; at six and 12 months, patients also completed Global Rating of Change Scales. Responsiveness was assessed using correlation coefficients and linear regression. Cox regression was used for mortality analyses. MCID was estimated using receiver operating characteristic curves with separate analyses for improvement and deterioration.

resultsA total of 150 IPF patients were included and 124 completed the 12-month follow-up. Based on all HRQL anchors and most physiological anchors, responsiveness analyses supported the evidence pointing towards SGRQ-I and K-BILD as responsive instruments. Multivariate analyses showed an association between SGRQ-I and mortality (HR: 1.18, 95% CI: 1.02 to 1.36, p = 0.03) and a trend was found for K-BILD (HR: 0.82, 95% CI: 0.64 to 1.05, p = 0.12). MCID was estimated for all domains of SGRQ-I and K-BILD. MCID for improvement differed from deterioration for both SGRQ-I Total (3.9 and 4.9) and K-BILD Total (4.7 and 2.7).

conclusionsSGRQ-I and K-BILD were responsive to change concerning both HRQL and most physiological anchors. MCID was determined separately for improvement and deterioration, resulting in different estimates; especially a smaller estimate for deterioration compared to improvement in K-BILD.

trial registrationClinicaltrials.gov, no. NCT02818712. Registered 30 June 2016.

Indexed as

Minimal Clinically Important DifferenceAgedCohort StudiesFemaleHumansIdiopathic Pulmonary FibrosisLung Diseases, InterstitialMaleMiddle AgedProspective StudiesQuality of LifeTreatment OutcomeWalk TestHealth-related quality of lifeIdiopathic pulmonary fibrosisIPFIPF-specific version of St. Georges respiratory questionnaireK-BILDKing’s Brief Interstitial Lung Disease questionnaireLongitudinal validityminimal clinically important differenceResponsivenessSGRQ-I

Identifiers

PMID32316976
PMCPMC7175493
OpenAlexW3016978528

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.