ArticleJournal of the Royal Society, Interface2020
Interfering with influenza: nonlinear coupling of reactive and static mitigation strategies.
Article in Journal of the Royal Society, Interface, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Multi-scale phylodynamic modelling of rapid punctuated pathogen evolution.PLoS computational biology · 2025Article
- Bounded risk disposition explains Turing patterns and tipping points during spatial contagions.Royal Society open science · 2024Article
- Persistence of the Omicron variant of SARS-CoV-2 in Australia: The impact of fluctuating social distancing.PLOS global public health · 2023Article
- A general framework for optimising cost-effectiveness of pandemic response under partial intervention measures.Scientific reports · 2022Article
- The effects of local homogeneity assumptions in metapopulation models of infectious disease.Royal Society open science · 2022Article
- Simulating Transmission Scenarios of the Delta Variant of SARS-CoV-2 in Australia.Frontiers in public health · 2022Article
- How will mass-vaccination change COVID-19 lockdown requirements in Australia?The Lancet regional health. Western Pacific · 2021Article
- Risk mapping for COVID-19 outbreaks in Australia using mobility data.Journal of the Royal Society, Interface · 2021Article
- Modelling transmission and control of the COVID-19 pandemic in Australia.Nature communications · 2020Article
- Modelling Excess Mortality in Covid-19-Like Epidemics.Entropy (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When new, highly infectious strains of influenza emerge, global pandemics can occur before an effective vaccine is developed. Without a strain-specific vaccine, pandemics can only be mitigated by employing combinations of low-efficacy pre-pandemic vaccines and reactive response measures that are carried out as the pandemic unfolds. Unfortunately, the application of reactive interventions can lead to unintended consequences that may exacerbate unpredictable spreading dynamics and cause more drawn-out epidemics. Here, we employ a detailed model of pandemic influenza in Australia to simulate the combination of pre-pandemic vaccination and reactive antiviral prophylaxis. This study focuses on population-level coupling effects between the respective methods, and the associated spatio-temporal fluctuations in pandemic dynamics produced by reactive strategies. Our results show that combining strategies can produce either mutual improvement of performance or interference that reduces the effectiveness of each strategy when they are used together. We demonstrate that these coupling effects between intervention strategies are extremely sensitive to delay times, compliance rates and the type of contact targeting used to administer prophylaxis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.