Evidence map›Paper›PMID 32316697›Full record

ArticleCells2020

MiR193a Modulation and Podocyte Phenotype.

Alok Jha, Shourav Saha, Kamesh Ayasolla, Himanshu Vashistha, Ashwani Malhotra, Karl Skorecki, Pravin C Singhal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Transcriptomic Analysis of Human PodocytesKidney international reports · 2023
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Alok JhaInstitute of Molecular Medicine, Feinstein Institute for Medical Research and Zucker School of Medicine at Hofstra-North well, New York, NY 11030, USA.
Shourav SahaInstitute of Molecular Medicine, Feinstein Institute for Medical Research and Zucker School of Medicine at Hofstra-North well, New York, NY 11030, USA.
Kamesh AyasollaInstitute of Molecular Medicine, Feinstein Institute for Medical Research and Zucker School of Medicine at Hofstra-North well, New York, NY 11030, USA.
Himanshu VashisthaInstitute of Molecular Medicine, Feinstein Institute for Medical Research and Zucker School of Medicine at Hofstra-North well, New York, NY 11030, USA.
Ashwani MalhotraInstitute of Molecular Medicine, Feinstein Institute for Medical Research and Zucker School of Medicine at Hofstra-North well, New York, NY 11030, USA.
Karl SkoreckiTechnion - Israel Institute of Technology, and Rambam Health Care Campus, Haifa 2710000, Israel.
Pravin C SinghalInstitute of Molecular Medicine, Feinstein Institute for Medical Research and Zucker School of Medicine at Hofstra-North well, New York, NY 11030, USA.
Feinstein Institute for Medical Research · USTechnion – Israel Institute of Technology · IL

Funding

Epigenetic factors and HIV-associated NephropathyR01DK098074 · NIDDK · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI SINGHAL, PRAVIN C · 2013 to 2016
$2.5M
APOL1 in Diabetic PodocytopathyR01DK118017 · NIDDK · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI SINGHAL, PRAVIN C · 2018 to 2021
$2.0M
NIDDK NIH HHS R01 DK098074NIDDK NIH HHS R01 DK118017
6 · The paper itself

Abstract

Apolipoprotein L1 (APOL1)-miR193a axis has been reported to play a role in the maintenance of podocyte homeostasis. In the present study, we analyzed transcription factors relevant to miR193a in human podocytes and their effects on podocytes' molecular phenotype. The motif scan of the miR193a gene provided information about transcription factors, including YY1, WT1, Sox2, and VDR-RXR heterodimer, which could potentially bind to the miR193a promoter region to regulate miR193a expression. All structure models of these transcription factors and the tertiary structures of the miR193a promoter region were generated and refined using computational tools. The DNA-protein complexes of the miR193a promoter region and transcription factors were created using a docking approach. To determine the modulatory role of miR193a on

Indexed as

PhenotypeCell DifferentiationDown-RegulationHumansMicroRNAsPodocytesReceptors, CalcitriolSOXB1 Transcription FactorsTranscription FactorsYY1 Transcription FactorMicroRNAsMIRN193 microRNA, humanReceptors, CalcitriolSOX2 protein, humanSOXB1 Transcription FactorsTranscription FactorsVDR protein, humanYY1 protein, humanYY1 Transcription FactorAPOL1miR193aRXRSox2VDRWT1YY1

Identifiers

PMID32316697
PMCPMC7226544
OpenAlexW3016666755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.