Evidence map›Paper›PMID 32316568›Full record

ArticlePharmaceuticals (Basel, Switzerland)2020

Electroanalysis Applied to Compatibility and Stability Assays of Drugs: Carvedilol Study Case.

Murilo Ferreira de Carvalho, Luane Ferreira Garcia, Isaac Yves Lopes de Macedo, Ricardo Neves Marreto, Mayk Teles de Oliveira, Renê Oliveira do Couto, Carlos Eduardo Peixoto da Cunha, Karla Carneiro de Siqueira Leite, Kênnia Rocha Rezende, Fabio Bahls Machado and 2 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Murilo Ferreira de CarvalhoFaculty of Pharmacy, Federal University of Goiás, Goiânia 74605-170, Brazil.ORCID 0000-0001-6438-5702
Luane Ferreira GarciaFaculty of Pharmacy, Federal University of Goiás, Goiânia 74605-170, Brazil.
Isaac Yves Lopes de MacedoFaculty of Pharmacy, Federal University of Goiás, Goiânia 74605-170, Brazil.ORCID 0000-0002-6043-5343
Ricardo Neves MarretoFaculty of Pharmacy, Federal University of Goiás, Goiânia 74605-170, Brazil.
Mayk Teles de OliveiraFaculty of Pharmacy, Federal University of Goiás, Goiânia 74605-170, Brazil.
Renê Oliveira do CoutoPharmacy School, Federal University of São João del-Rei, Midwest Campus, Divinópolis-MG, ZIP 35.501-296, Brazil.
Carlos Eduardo Peixoto da CunhaFaculty of Pharmacy, Federal University of Goiás, Goiânia 74605-170, Brazil.
Karla Carneiro de Siqueira LeiteUniversidade Paulista, Goiânia, GO 74845-090, Brazil.ORCID 0000-0002-3645-0252
Kênnia Rocha RezendeFaculty of Pharmacy, Federal University of Goiás, Goiânia 74605-170, Brazil.ORCID 0000-0002-3813-8545
Fabio Bahls MachadoFaculty of Pharmacy, Federal University of Goiás, Goiânia 74605-170, Brazil.
Vernon SomersetDepartment of Chemistry, Faculty of Applied Sciences, Cape Peninsula University of Technology, Bellville 7535, South Africa.ORCID 0000-0001-8643-1853
Eric de Souza GilFaculty of Pharmacy, Federal University of Goiás, Goiânia 74605-170, Brazil.ORCID 0000-0001-9161-0127
Universidade Federal de Goiás · BRCape Peninsula University of Technology · ZAFederal University of São João del-Rei · BRUniversidade Paulista · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 304676/2017-9Coordenação de Aperfeiçoamento de Pessoal de Nível Superior scolar ships PNPDFundação de Amparo à Pesquisa do Estado de Goiás PRONEN 2017
6 · The paper itself

Abstract

Carvedilol (CRV) is a non-selective blocker of α and β adrenergic receptors, which has been extensively used for the treatment of hypertension and congestive heart failure. Owing to its poor biopharmaceutical properties, CRV has been incorporated into different types of drug delivery systems and this necessitates the importance of investigating their compatibility and stability. In this sense, we have investigated the applicability of several electroanalytical tools to assess CRV compatibility with lipid excipients. Voltammetric and electrochemical impedance spectroscopy techniques were used to evaluate the redox behavior of CRV and lipid excipients. Results showed that Plurol

Indexed as

anti-hypertensivesdrug delivery systemselectrochemical impedance spectroscopyelectrochemistryexcipientspharmaceutical technology

Identifiers

PMID32316568
PMCPMC7243106
OpenAlexW3017265438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.