ArticleJournal of clinical medicine2020
Relative Handgrip Strength Diminishes the Negative Effects of Excess Adiposity on Dependence in Older Adults: A Moderation Analysis.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Can Muscle Mass Be Maintained with A Simple Resistance Intervention in the Older People? A Cluster Randomized Controlled Trial in Thailand.International journal of environmental research and public health · 2021Trial
- Longitudinal Changes in Body Composition, Adaptive Thermogenesis, and Muscle Strength in Patients with Obesity Treated with Semaglutide.Obesity facts · 2026Article
- Visceral-to-peripheral adiposity ratio in proneness to sarcopenic obesity: association with low muscle strength, but not low muscle mass, in young women of South Asian descent.International journal of obesity (2005) · 2026Article
- Moderation Effect of Handgrip Strength on Cognition and Functional Independence Associations in Adults Over 90 Years.Journal of cachexia, sarcopenia and muscle · 2025Article
- Relationship Between Triglyceride-Glucose Index and Handgrip Strength in the Midlife and Elderly Population: Evidence From a Chinese Cohort.International journal of endocrinology · 2025Article
- Association of triglyceride-glucose index and its related parameters with functional disability: evidence from the China Health and Retirement Longitudinal Study.Frontiers in aging neuroscience · 2025Article
- Association between dynapenic obesity phenotypes and physical performance in middle-age and older women living in community.Frontiers in nutrition · 2024Article
- Association between handgrip strength and the risk of new-onset metabolic syndrome: a population-based cohort study.BMJ open · 2020Article
- Circulating Cytokines and Lower Body Muscle Performance in Older Adults at Hospital Admission.The journal of nutrition, health & aging · 2020Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
The adverse effects of fat mass on functional dependence might be attenuated or worsened, depending on the level of muscular strength. The aim of this study was to determine (i) the detrimental effect of excess adiposity on dependence in activities of daily living (ADL), and (ii) whether relative handgrip strength (HGS) moderates the adverse effect of excess adiposity on dependence, and to provide the threshold of relative HGS from which the adverse effect could be improved or worsened. A total of 4169 participants (69.3 ± 7.0 years old) from 244 municipalities were selected following a multistage area probability sampling design. Measurements included anthropometric/adiposity markers (weight, height, body mass index, waist circumference, and waist-to-height ratio (WHtR)), HGS, sarcopenia "proxy" (calf circumference), and ADL (Barthel Index scale). Moderation analyses were performed to identify associations between the independent variable (relative HGS) and outcomes (dependence), as well as to determine whether relative HGS moderates the relationship between excess adiposity and dependence. The present study demonstrated that (i) the adverse effect of having a higher WHtR level on dependence in ADL was moderated by relative HGS, and (ii) two moderation thresholds of relative HGS were estimated: 0.35, below which the adverse effect of WHtR levels on dependency is aggravated, and 0.62, above which the adverse effect of fat on dependency could be improved. Because muscular strength represents a critically important and modifiable predictor of ADL, and the increase in adiposity is inherent in aging, our results underscore the importance of an optimal level of relative HGS in the older adult population.
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Registered trials
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