Evidence map›Paper›PMID 32316405›Full record

ArticleInternational journal of environmental research and public health2020

Inhibition of miR-141 and miR-200a Increase

Norhazlina Abdul Wahab, Zahreena Othman, Noor Wahidah Mohd Nasri, Mohd Helmy Mokhtar, Siti Fatimah Ibrahim, Adila A Hamid, Raja Affendi Raja Ali, Norfilza Mohd Mokhtar

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Reference Genes for qPCR-Based miRNA Expression Profiling in 14 Human Tissues.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2022
    Review
  7. Article
  8. Role of miRNA-19a in Cancer Diagnosis and Poor Prognosis.International journal of molecular sciences · 2021
    Review
  9. Review
  10. Article
  11. Article
  12. Expression of Circulating MicroRNA-141 in Epithelial Ovarian Cancer.The Malaysian journal of medical sciences : MJMS · 2020
    Article
  13. The Role of microRNAs in Epithelial Ovarian Cancer Metastasis.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Norhazlina Abdul WahabDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Zahreena OthmanDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Noor Wahidah Mohd NasriDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Mohd Helmy MokhtarDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Siti Fatimah IbrahimDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Adila A HamidDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Raja Affendi Raja AliDepartment of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Norfilza Mohd MokhtarDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
National University of Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of microRNA (miRNA) in ovarian cancer has been extensively studied as a regulator for its targeted genes. However, its specific role in metastatic serous ovarian cancer (SOC) is yet to be explored. This paper aims to investigate the differentially expressed miRNAs in metastatic SOC compared to normal. Locked nucleic acid PCR was performed to profile miRNA expression in 11 snap frozen metastatic SOC and 13 normal ovarian tissues. Functional analysis and regulation of their targeted genes were assessed in vitro. Forty-eight miRNAs were significantly differentially expressed in metastatic SOC as compared to normal. MiR-19a is a novel miRNA to be upregulated in metastatic SOC compared to normal.

Indexed as

Carcinoma, Ovarian EpithelialCystadenocarcinoma, SerousGTPase-Activating ProteinsMicroRNAsOvarian NeoplasmsTumor Suppressor ProteinsZinc Finger E-box Binding Homeobox 2Cell Line, TumorCell MovementFemaleGene Expression Regulation, NeoplasticHumansMiddle AgedDLC1 protein, humanGTPase-Activating ProteinsMicroRNAsMIRN141 microRNA, humanMIRN200 microRNA, humanTumor Suppressor ProteinsZEB2 protein, humanZinc Finger E-box Binding Homeobox 2metastasismicroRNAMIRN141 microRNAMIRN200 microRNAserous ovarian cancer

Identifiers

PMID32316405
PMCPMC7215320
OpenAlexW3017007417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.