Evidence map›Paper›PMID 32316285›Full record

ArticleMolecules (Basel, Switzerland)2020

Improved Detection of Molecular Markers of Atherosclerotic Plaques Using Sub-Millimeter PET Imaging.

Jessica Bridoux, Sara Neyt, Pieterjan Debie, Benedicte Descamps, Nick Devoogdt, Frederik Cleeren, Guy Bormans, Alexis Broisat, Vicky Caveliers, Catarina Xavier and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Immuno-positron emission tomography in cardiovascular disease: Advances, challenges, and opportunities.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2026
    Review
  2. From incidental positron emission uptake toFrontiers in cardiovascular medicine · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Jessica BridouxLaboratory of In Vivo Cellular and Molecular Imaging (ICMI, BEFY-MIMA), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.ORCID 0000-0002-8895-9763
Sara NeytPreclinical imaging, MOLECUBES NV, 9000 Ghent, Belgium.
Pieterjan DebieLaboratory of In Vivo Cellular and Molecular Imaging (ICMI, BEFY-MIMA), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.ORCID 0000-0002-9128-7814
Benedicte DescampsIBiTech-MEDISIP, Ghent University, 9000 Ghent, Belgium.
Nick DevoogdtLaboratory of In Vivo Cellular and Molecular Imaging (ICMI, BEFY-MIMA), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.ORCID 0000-0001-9220-4833
Frederik CleerenRadiopharmaceutical Research, KU Leuven, 3000 Leuven, Belgium.
Guy BormansRadiopharmaceutical Research, KU Leuven, 3000 Leuven, Belgium.
Alexis BroisatRadiopharmaceutiques Biocliniques, INSERM 1039, Université de Grenoble, 38400 Grenoble, France.ORCID 0000-0002-4265-8463
Vicky CaveliersLaboratory of In Vivo Cellular and Molecular Imaging (ICMI, BEFY-MIMA), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
Catarina XavierLaboratory of In Vivo Cellular and Molecular Imaging (ICMI, BEFY-MIMA), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
Christian VanhoveIBiTech-MEDISIP, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0002-3988-5980
Sophie HernotLaboratory of In Vivo Cellular and Molecular Imaging (ICMI, BEFY-MIMA), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
Vrije Universiteit Brussel · BEGhent University · BEKU Leuven · BEInserm · FR

Funding

Fonds Wetenschappelijk Onderzoek G005815NFonds Wetenschappelijk Onderzoek G0D8817NH2020 Marie Skłodowska-Curie Actions 675417 PET3D
6 · The paper itself

Abstract

Since atherosclerotic plaques are small and sparse, their non-invasive detection via PET imaging requires both highly specific radiotracers as well as imaging systems with high sensitivity and resolution. This study aimed to assess the targeting and biodistribution of a novel fluorine-18 anti-VCAM-1 Nanobody (Nb), and to investigate whether sub-millimetre resolution PET imaging could improve detectability of plaques in mice. The anti-VCAM-1 Nb functionalised with the novel restrained complexing agent (RESCA) chelator was labelled with [

Indexed as

AnimalsAntibodiesBiomarkersDisease Models, AnimalFluorine RadioisotopesHumansInjectionsMiceMolecular ImagingPlaque, AtheroscleroticPositron Emission Tomography Computed TomographyRadiopharmaceuticalsTissue DistributionVascular Cell Adhesion Molecule-1AntibodiesBiomarkersFluorine-18Fluorine RadioisotopesRadiopharmaceuticalsVascular Cell Adhesion Molecule-1AlF-radiolabellingmolecular imagingnanobodyPET imagingsingle-domain antibodysub-millimetre resolutionvulnerable plaque

Identifiers

PMID32316285
PMCPMC7221983
OpenAlexW3016932722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.