ArticleCells2020
FTO Intronic SNP Strongly Influences Human Neck Adipocyte Browning Determined by Tissue and PPARγ Specific Regulation: A Transcriptome Analysis.
Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 0 citations in OpenAlex.
- Thermogenic Differentiation of Human Adipocyte Precursors in Culture: A Systematic Review.Cells · 2025Pooled it
- Regulatory modules of human thermogenic adipocytes: functional genomics of large cohort and Meta-analysis derived marker-genes.BMC genomics · 2021Pooled it
- Transferrin receptor 1-mediated iron uptake supports thermogenic activation in human cervical-derived adipocytes.FEBS letters · 2026Article
- Thiamine transporter 2 and Janus kinase 2 inhibitor, fedratinib suppresses thermogenic activation of human neck area-derived adipocytes.Frontiers in endocrinology · 2026Article
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- α2 adrenoceptors, cold-induced vasoconstriction, and Raynaud's phenomenon.Cell genomics · 2025Article
- Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele.Nature communications · 2025Article
- RNA modifications and their role in gene expression.Frontiers in molecular biosciences · 2025Review
- Upregulation of inhibitor of DNA binding 1 and 3 is important for efficient thermogenic response in human adipocytes.Scientific reports · 2024Article
- Genetic evidence for involvement of β2-adrenergic receptor in brown adipose tissue thermogenesis in humans.International journal of obesity (2005) · 2024Article
- The value of neck adipose tissue as a predictor for metabolic risk in health and type 2 diabetes.Biochemical pharmacology · 2024Article
- Article
- Extracellular thiamine concentration influences thermogenic competency of differentiating neck area-derived human adipocytes.Frontiers in nutrition · 2023Article
- Human abdominal subcutaneous-derived active beige adipocytes carryingFrontiers in cell and developmental biology · 2023Article
- Tissue Transglutaminase Knock-Out Preadipocytes and Beige Cells of Epididymal Fat Origin Possess Decreased Mitochondrial Functions Required for Thermogenesis.International journal of molecular sciences · 2022Article
- The neutral amino acid transporter SLC7A10 in adipose tissue, obesity and insulin resistance.Frontiers in cell and developmental biology · 2022Review
- The role of RNA m6A methylation in lipid metabolism.Frontiers in endocrinology · 2022Review
- Article
- BMP7 Increases UCP1-Dependent and Independent Thermogenesis with a Unique Gene Expression Program in Human Neck Area Derived Adipocytes.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Search for Possible Associations ofPharmacogenomics and personalized medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brown adipocytes, abundant in deep-neck (DN) area in humans, are thermogenic with anti-obesity potential. FTO pro-obesity rs1421085 T-to-C single-nucleotide polymorphism (SNP) shifts differentiation program towards white adipocytes in subcutaneous fat. Human adipose-derived stromal cells were obtained from subcutaneous neck (SC) and DN fat of nine donors, of which 3-3 carried risk-free (T/T), heterozygous or obesity-risk (C/C) FTO genotypes. They were differentiated to white and brown (long-term Peroxisome proliferator-activated receptor gamma (PPARγ) stimulation) adipocytes; then, global RNA sequencing was performed and differentially expressed genes (DEGs) were compared. DN and SC progenitors had similar adipocyte differentiation potential but differed in DEGs. DN adipocytes displayed higher browning features according to ProFAT or BATLAS scores and characteristic DEG patterns revealing associated pathways which were highly expressed (thermogenesis, interferon, cytokine, and retinoic acid, with
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.