ReviewCells2020
Male Infertility is a Women's Health Issue-Research and Clinical Evaluation of Male Infertility Is Needed.
Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 223 citations in OpenAlex.
- Evaluation of the association between polymorphisms of PRM1 and PRM2 and the risk of male infertility: a systematic review, meta-analysis, and meta-regression.Scientific reports · 2020Pooled it
- Heat exposure during susceptible windows of spermatogenesis and sperm epigenetic age.Human reproduction (Oxford, England) · 2026Trial
- The Effect of Palm Pollen and Black Seed Pollen on Male Sex Hormones and Sperm Quality: A Single-Blind, Placebo-Controlled Clinical Trial Study.International journal of fertility & sterility · 2023Trial
- Development of a Noble On-Site Dual Screening System for Male Fertility of Sperm Count and Hyaluronidase Activity.The world journal of men's health · 2026Article
- Epigenetic sperm quality testing for predicting fertility treatment success: a real-world and multi-site analysis.Journal of assisted reproduction and genetics · 2026Article
- Cadmium-Induced Testicular and Spermatogonial Damage Ameliorated by Bryonia laciniosa Linn. Seeds in Wistar Rats: An Animal Study.Biological trace element research · 2026Article
- The impact of neighborhood socioeconomic status and racial composition on semen quality.AJOG global reports · 2026Article
- Article
- Mindfulness-based counseling for sexual relational concern in infertile women: A clinical trial protocol.Journal of education and health promotion · 2026Article
- Relationship Between Resilience and Fertility Quality of Life in Infertile Women: Mediating Roles of Infertility Self-Efficacy and Infertility Coping.Healthcare (Basel, Switzerland) · 2025Article
- Global, regional, and national burden and trend of infertility and its subtypes from 1990 to 2021, with projections to 2035.Journal of assisted reproduction and genetics · 2025Article
- The Role of Preconception Parental Health on Embryo Quality-Preliminary Results of a Prospective Study Using Non-Invasive Preimplantation Genetic Testing for Aneuploidy.Biomolecules · 2025Article
- Novel insights into the lipid signalling in human spermatozoa.Human reproduction (Oxford, England) · 2025Review
- Article
- A Qualitative Study of the Emotional and Decision-Making Experiences of Mothers Whose Daughter Undergoes Assisted Reproductive Technology with Donor Sperm.International journal of women's health · 2025Article
- Gender Biases in Male Infertility and Its Impact on Women: A Qualitative Exploration.Nursing research and practice · 2025Article
- The Intricate Functional Networks of Pre-mRNA Alternative Splicing in Mammalian Spermatogenesis.International journal of molecular sciences · 2024Review
- Novel approach for oligospermia (NAPO) - Protocol for a randomized controlled trial.Contemporary clinical trials communications · 2024Article
- Bidirectional Mendelian randomization to explore the causal relationships between the gut microbiota and male reproductive diseases.Scientific reports · 2024Article
- Association between Sperm Mitochondrial DNA Copy Number and Concentrations of Urinary Cadmium and Selenium.Biological trace element research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Infertility is a devastating experience for both partners as they try to conceive. Historically, when a couple could not conceive, the woman has carried the stigma of infertility; however, men and women are just as likely to contribute to the couple's infertility. With the development of assisted reproductive technology (ART), the treatment burden for male and unexplained infertility has fallen mainly on women. Equalizing this burden requires reviving research on male infertility to both improve treatment options and enable natural conception. Despite many scientific efforts, infertility in men due to sperm dysfunction is mainly diagnosed by a semen analysis. The semen analysis is limited as it only examines general sperm properties such as concentration, motility, and morphology. A diagnosis of male infertility rarely includes an assessment of internal sperm components such as DNA, which is well documented to have an impact on infertility, or other components such as RNA and centrioles, which are beginning to be adopted. Assessment of these components is not typically included in current diagnostic testing because available treatments are limited. Recent research has expanded our understanding of sperm biology and suggests that these components may also contribute to the failure to achieve pregnancy. Understanding the sperm's internal components, and how they contribute to male infertility, would provide avenues for new therapies that are based on treating men directly for male infertility, which may enable less invasive treatments and even natural conception.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.