Evidence map›Paper›PMID 32316186›Full record

ArticleCancers2020

Near-Infrared Molecular Imaging of Glioblastoma by Miltuximab

Dmitry M Polikarpov, Douglas H Campbell, Lucinda S McRobb, Jiehua Wu, Maria E Lund, Yanling Lu, Sergey M Deyev, Andrew S Davidson, Bradley J Walsh, Andrei V Zvyagin and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  6. Article
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  8. Glioblastoma vaccine tumor therapy research progress.Chinese neurosurgical journal · 2022
    Review
  9. Fluorescent intraoperative navigation: trends and beyond.American journal of nuclear medicine and molecular imaging · 2022
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Dmitry M PolikarpovDepartment of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia.ORCID 0000-0002-3783-723X
Douglas H CampbellGlytherix Ltd., Sydney, NSW 2113, Australia.
Lucinda S McRobbDepartment of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia.ORCID 0000-0001-5492-1903
Jiehua WuGlytherix Ltd., Sydney, NSW 2113, Australia.
Maria E LundGlytherix Ltd., Sydney, NSW 2113, Australia.
Yanling LuGlytherix Ltd., Sydney, NSW 2113, Australia.
Sergey M DeyevShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia.
Andrew S DavidsonDepartment of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia.
Bradley J WalshGlytherix Ltd., Sydney, NSW 2113, Australia.
Andrei V ZvyaginShemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997 Moscow, Russia.ORCID 0000-0001-8799-2257
David A GillattDepartment of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia.
Macquarie University · AUInstitute of Bioorganic Chemistry · RUSechenov University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) is one of the most aggressive tumors and its 5-year survival is approximately 5%. Fluorescence-guided surgery (FGS) improves the extent of resection and leads to better prognosis. Molecular near-infrared (NIR) imaging appears to outperform conventional FGS, however, novel molecular targets need to be identified in GBM. Proteoglycan glypican-1 (GPC-1) is believed to be such a target as it is highly expressed in GBM and is associated with poor prognosis. We hypothesize that an anti-GPC-1 antibody, Miltuximab

Indexed as

brain neoplasmfluorescence-guided surgeryglypican-1IRDye800CWMiltuximabmolecular imagingmonoclonal antibodies

Identifiers

PMID32316186
PMCPMC7226459
OpenAlexW3016949284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.