ReviewMolecules (Basel, Switzerland)2020
Hypolipidemic Effects of β-Glucans, Mannans, and Fucoidans: Mechanism of Action and Their Prospects for Clinical Application.
Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The effect of glucomannan supplementation on lipid profile in adults: a GRADE-assessed systematic review and meta-analysis.BMC cardiovascular disorders · 2024Pooled it
- Consumer Perceptions Influence Supplement Choice: A Narrative Review of Clinically Studied Weight-Management Supplements in Obesity.Nutrients · 2026Review
- Effect of Doum (Frontiers in nutrition · 2026Article
- Effects of yeast cell wall, bacterial supplement, and thistle extract on performance, organ health, cardiac factors, and immunity in broilers exposed to aflatoxin and ochratoxin.Tropical animal health and production · 2025Article
- Size reduction of selenium nanoparticles synthesized from yeast beta glucan using cold atmospheric plasma.Scientific reports · 2025Article
- Therapeutic potential of microalgae-derived natural compounds in diabetic wound healing: A comprehensive review.Heliyon · 2025Review
- Combined clinical significance of MRI and serum mannose-binding lectin in the prediction of spinal tuberculosis.BMC infectious diseases · 2024Article
- Yeast cell wall mannan structural features, biological activities, and production strategies.Heliyon · 2024Review
- Mechanistic insights into rumen function promotion through yeast culture (Frontiers in microbiology · 2024Article
- Article
- Dietary supplementation with β-mannanase and probiotics as a strategy to improve laying hen performance and egg quality.Frontiers in veterinary science · 2023Article
- Immunomodulatory effect of polysaccharides isolated fromHeliyon · 2022Article
- Application of fucoidan as treatment for cardiovascular and cerebrovascular diseases.Therapeutic advances in chronic disease · 2022Review
- Structural Elucidation and Activities ofFrontiers in nutrition · 2022Review
- Polymer-Based Nanosystems-A Versatile Delivery Approach.Materials (Basel, Switzerland) · 2021Review
- TheFrontiers in molecular biosciences · 2021Article
- Synergetic Action of Forskolin and Mevastatin Induce Normalization of Lipids Profile in Dyslipidemic Rats through Adenosine Monophosphate Kinase Upregulation.BioMed research international · 2021Article
- Therapeutic effects of different doses of prebiotic (isolated from SDiabetology & metabolic syndrome · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The search for lipid-lowering drugs is important for clinical medicine. This review summarizes our research findings regarding the hypolipidemic activity of polysaccharides. There are several validated agents altering lipid levels which reduce the risk of atherosclerotic cardiovascular events. Nonetheless, for many people, the risk of such an event remains unacceptably high despite treatment with these agents. This situation has prompted the search for new therapies to reduce the residual cardiovascular risk. The lipid-lowering effect of β-glucans consumed with food was demonstrated in patients with atherosclerosis. The mechanism of the protective effect of β-glucans is poorly studied. The effects of β-glucans are mediated by Toll-like receptors, by dectin-1, and possibly by other receptors. Nevertheless, the mechanism of the protective action of β-glucan in lipemic mice has been studied insufficiently. This review will present up-to-date information regarding experimental hypolipidemic polysaccharide compounds that hold promise for medicine. Phagocyte-specific chitotriosidase in humans contributes to innate immune responses against chitin-containing fungi. This enzyme has been first described in patients with Gaucher disease and serves as an important diagnostic biomarker. It has been reported that, in mice, chitin particles of certain size are recognized by macrophages through Toll-like receptors, dectin-1, and to a lesser extent through mannose receptor.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.