ArticleJournal of clinical medicine2020
Global Spread of Coronavirus Disease 2019 and Malaria: An Epidemiological Paradox in the Early Stage of A Pandemic.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- COVID-19 and malaria co-infection: a systematic review of clinical outcomes in endemic areas.PeerJ · 2024Pooled it
- Seroprevalence of anti-SARS-CoV-2 and anti-Plasmodium falciparum and vivax antibodies in urban and rural zones in the West Region of Cameroon.BMC infectious diseases · 2025Article
- Emergence of coinfection with visceral Leishmania infantum in COVID-19 patients: a case‒control field study in an endemic area of visceral leishmaniasis in Iran.BMC infectious diseases · 2024Article
- Coronavirus disease 2019 and malaria coinfection in a middle-aged Ethiopian woman presenting with acute febrile illness and bilateral pleural effusion: a case report.Journal of medical case reports · 2023Article
- COVID-19 Infection in Rheumatic Patients on Chronic Antimalarial Drugs: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Review
- Impact of COVID-19 and malaria coinfection on clinical outcomes: a retrospective cohort study.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022Article
- Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa.Tropical medicine and infectious disease · 2022Article
- Lessons for improved COVID-19 surveillance from the scale-up of malaria testing strategies.Malaria journal · 2022Review
- Low incidence of COVID-19 case severity and mortality in Africa; Could malaria co-infection provide the missing link?BMC infectious diseases · 2022Review
- Seroreactivity of the Severe Acute Respiratory Syndrome Coronavirus 2 Recombinant S Protein, Receptor-Binding Domain, and Its Receptor-Binding Motif in COVID-19 Patients and Their Cross-Reactivity With Pre-COVID-19 Samples From Malaria-Endemic Areas.Frontiers in immunology · 2022Article
- Epidemiological Trends of Coronavirus Disease 2019 in Sierra Leone From March 2020 to October 2021.Frontiers in public health · 2022Article
- Is Endemicity a Solution for the COVID-19 Pandemic? The Four E's Strategy for the Public Health Leadership.Frontiers in public health · 2022Article
- Potential for Further Mismanagement of Fever During COVID-19 Pandemic: Possible Causes and Impacts.Frontiers in medicine · 2022Article
- Long-term ocular damage after recovery from COVID-19: lack of evidence at three months.BMC ophthalmology · 2021Article
- Malaria, COVID-19 and angiotensin-converting enzyme 2: what does the available population data say?Open biology · 2021Review
- COVID-19: Mechanistic Model of the African Paradox Supports the Central Role of the NF-κB Pathway.Viruses · 2021Review
- The association between malaria prevalence and COVID-19 mortality.BMC infectious diseases · 2021Article
- COVID-19 and blood groups: A six-months observational study in Ferrara, Italy.Hematology reports · 2021Article
- The New Status of Parasitic Diseases in the COVID-19 Pandemic-Risk Factors or Protective Agents?Journal of clinical medicine · 2021Review
- Spatial Variability in COVID-19 Mortality.International journal of environmental research and public health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the current work, we discovered and analyzed the epidemiological paradox between coronavirus disease 2019 (COVID-19) and malaria in the initial phase of the ongoing pandemic. From the analysis of distribution data, the endemic presence of malaria seems to protect some populations from COVID-19 outbreak, particularly in the least developed countries. In this sense, molecular and genetic variations associated with malaria (e.g., in ACE2) might play a protective role against coronavirus infection. Moreover, the mechanism of action of some antimalarial drugs, e.g., the antiviral function, suggests their potential role in the chemoprophylaxis of coronavirus epidemics, despite possible adverse effects (e.g., retinal toxicity). All these data provide important insights to understand the spreading mechanisms of COVID-19, and to direct scientific research toward the study of some currently available medications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.