Evidence map›Paper›PMID 32316101›Full record

ArticlePharmaceuticals (Basel, Switzerland)2020

Evaluation of the Anti-Tumor Activity of Small Molecules Targeting Eph/Ephrins in APC

Miriam Corrado, Carmine Giorgio, Elisabetta Barocelli, Giuseppe Vittucci Marzetti, Anna Maria Cantoni, Rosanna Di Lecce, Matteo Incerti, Riccardo Castelli, Alessio Lodola, Massimiliano Tognolini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Miriam CorradoFood and Drug Department, University of Parma, Viale delle Scienze 27/a, 43124 Parma, Italy.ORCID 0000-0002-4277-6398
Carmine GiorgioFood and Drug Department, University of Parma, Viale delle Scienze 27/a, 43124 Parma, Italy.ORCID 0000-0001-6414-8221
Elisabetta BarocelliFood and Drug Department, University of Parma, Viale delle Scienze 27/a, 43124 Parma, Italy.ORCID 0000-0002-8152-3166
Giuseppe Vittucci MarzettiDepartment of Sociology and Social Research, University of Milano-Bicocca, Via Bicocca degli Arcimboldi 8, 20126 Milan, Italy.
Anna Maria CantoniDepartment of Veterinary Science, University of Parma, Strada del Taglio 10, 43126 Parma, Italy.
Rosanna Di LecceDepartment of Veterinary Science, University of Parma, Strada del Taglio 10, 43126 Parma, Italy.
Matteo IncertiFood and Drug Department, University of Parma, Viale delle Scienze 27/a, 43124 Parma, Italy.
Riccardo CastelliFood and Drug Department, University of Parma, Viale delle Scienze 27/a, 43124 Parma, Italy.
Alessio LodolaFood and Drug Department, University of Parma, Viale delle Scienze 27/a, 43124 Parma, Italy.
Massimiliano TognoliniFood and Drug Department, University of Parma, Viale delle Scienze 27/a, 43124 Parma, Italy.ORCID 0000-0002-4715-0407
University of Parma · ITUniversity of Milano-Bicocca · IT

Funding

Associazione Italiana per la Ricerca sul Cancro 15211
6 · The paper itself

Abstract

The Eph receptors are the largest receptors tyrosine kinases (RTKs) family in humans and together with ephrin ligands constitute a complex cellular communication system often dysregulated in many tumors. The role of the Eph-ephrin system in colorectal cancer (CRC) has been investigated and different expression of Eph receptors have been associated with tumor development and progression. In light of this evidence, we investigated if a pharmacological approach aimed at inhibiting Eph/ephrin interaction through small molecules could prevent tumor growth in APC

Indexed as

APC min/J micecolorectal cancer (CRC)Eph antagonistEphA receptorsEphB receptorsEph-ephrin systemFamilial adenomatous polyposis (FAP)UniPR129

Identifiers

PMID32316101
PMCPMC7243115
OpenAlexW3016571216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.