ArticleBritish journal of haematology2020
The prognostic effect of smoking status on intensively treated acute myeloid leukaemia - A Danish nationwide cohort study.
Article in British journal of haematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Triptonide Suppresses AML via PI3K/AKT Signaling: A Network Pharmacology Approach Validated by Molecular Docking and Experimental Studies.Current issues in molecular biology · 2026Article
- The burden dynamics of leukemia in China from 1990 to 2021: an epidemiological analysis of trends, risk factors, and projections to 2036.Preventive medicine reports · 2025Article
- Psychiatric and substance use disorders predict poor outcomes in older veterans with acute myeloid leukemia.Blood advances · 2025Article
- Global, regional, and national burden of acute myeloid leukemia, 1990-2021: a systematic analysis for the global burden of disease study 2021.Biomarker research · 2024Article
- Socioeconomic Status and Overall Survival Among Patients With Hematological Malignant Neoplasms.JAMA network open · 2024Article
- Smoking as a prognostic factor for survival in patients with disseminated germ cell cancer.Journal of the National Cancer Institute · 2023Article
- Effects of chemotherapy dose reductions in overweight patients with acute myeloid leukaemia: A Danish nationwide cohort study.British journal of haematology · 2022Article
- The Global Burden of Leukemia and Its Attributable Factors in 204 Countries and Territories: Findings from the Global Burden of Disease 2019 Study and Projections to 2030.Journal of oncology · 2022Article
- Correlation between tobacco control policies and mortality of haematological cancers across Europe: An ecological study.Tobacco prevention & cessation · 2021Article
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Abstract
With rising life expectancy, the importance of patient-related prognostic factors and how to integrate such data into clinical decision-making becomes increasingly important. The aim of this study was to evaluate the prognostic impact of smoking status in patients with acute myeloid leukaemia (AML) treated with intensive chemotherapy. We conducted a nationwide cohort study based on data obtained from the Danish National Leukaemia Registry (DNLR). The study comprised Danish patients aged 18-75 years, diagnosed with AML between 1 January 2000 and 31 December 2012. Medical records were reviewed and data on smoking status were collected. A total of 1040 patients (median age 59 years) were included, and 602 patients (58·9%) were categorised as ever-smokers and the remaining as never-smokers. Kaplan-Meier survival estimates revealed that ever-smokers had a significant shorter median overall survival (OS) at 17·2 months [95% CI (14·9;19·1)] compared to never-smokers at 24·5 months (95% CI [19·2;30·7]). Multivariate analysis revealed smoking status as a significant prognostic factor for inferior OS with a hazard ratio (HR) of 1·22 [95% CI (1·04;1·44)]. In conclusion, smoking status was found to be associated with inferior OS in intensively treated AML patients.
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