Evidence map›Paper›PMID 32316030›Full record

SynthesisPediatric research2021

Short-term efficacy of umbilical cord milking in preterm infants: systematic review and meta-analysis.

Joshuan J Barboza, Leonardo Albitres-Flores, Marco Rivera-Meza, Jaime Rodriguez-Huapaya, José Caballero-Alvarado, Vinay Pasupuleti, Adrian V Hernandez

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Joshuan J BarbozaUnidad de Revisiones Sistemáticas y Meta-análisis (URSIGET), Vicerrectorado de Investigacion, Universidad San Ignacio de Loyola (USIL), Lima, Peru. jbarbozameca@relaped.com.ORCID http://orcid.org/0000-0002-2896-1407
Leonardo Albitres-FloresTAU-RELAPED Group, Trujillo, Peru.
Marco Rivera-MezaTAU-RELAPED Group, Trujillo, Peru.
Jaime Rodriguez-HuapayaTAU-RELAPED Group, Trujillo, Peru.
José Caballero-AlvaradoTAU-RELAPED Group, Trujillo, Peru.
Vinay PasupuletiProEd Communications, Inc, Cleveland, OH, USA.
Adrian V HernandezHealth Outcomes, Policy, and Evidence Synthesis (HOPES) Group, University of Connecticut School of Pharmacy, Storrs, CT, USA.
Antenor Orrego Private University · PEL-3 Communications (United States) · USNational University of Trujillo · PEUniversidad San Ignacio de Loyola · PEUniversity of Connecticut · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo systematically evaluate short-term efficacy of UCM versus other interventions in preterm infants.

methodsSix engines were searched until February 2020 for randomized controlled trials (RCTs) assessing UCM versus immediate cord clamping (ICC), delayed cord clamping (DCC), or no intervention. Primary outcomes were overall mortality, intraventricular hemorrhage (IVH), and patent ductus arteriosus (PDA); secondary outcomes were need for blood transfusion, mean blood pressure (MBP), serum hemoglobin (Hb), and ferritin levels. Random-effects meta-analyses were used.

resultsFourteen RCTs (n = 1708) were included. In comparison to ICC, UCM did not decrease mortality (RR 0.5, 95% CI 0.2-1.1), IVH (RR 0.7, 95% CI 0.5-1.0), or PDA (RR 1.0, 95% CI 0.7-1.5). However, UCM reduced need of blood transfusion (RR 0.5, 95% CI 0.3-0.9) and increased MBP (MD 2.5 mm Hg, 95% CI 0.5-4.5), Hb (MD 1.2 g/dL, 95% CI 0.8-1.6), and ferritin (MD 151.4 ng/dL, 95% CI 59.5-243.3). In comparison to DCC, UCM did not reduce mortality, IVH, PDA, or need of blood transfusion but increased MBP (MD 3.7, 95% CI 0.6-6.9) and Hb (MD 0.3, 95% CI -0.2-0.8). Only two RCTs had high risk of bias.

conclusionsUCM did not decrease short-term clinical outcomes in comparison to ICC or DCC in preterm infants. Intermediate outcomes improved significantly with UCM. IMPACT: In 14 randomized controlled trials (RCTs), umbilical cord milking (UCM) did not reduce mortality, intraventricular hemorrhage, or patent ductus arteriosus compared to immediate (ICC) or delayed cord clamping (DCC). UCM improved mean blood pressure and hemoglobin levels compared to ICC or DCC. In comparison to ICC, UCM reduced the need for blood transfusion. We updated searches until February 2020, stratified by type of control, and performed subgroup analyses. There was low quality of evidence about clinical efficacy of UCM. Most of RCTs had low risk of bias. UCM cannot be recommended as standard of care for preterm infants.

Indexed as

Blood TransfusionFetal BloodInfant, PrematurePremature BirthConstrictionGestational AgeHospital MortalityHumansInfantInfant MortalityInfant, NewbornRandomized Controlled Trials as TopicRisk AssessmentRisk FactorsTime FactorsTreatment Outcome

Identifiers

PMID32316030
OpenAlexW3016420732

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.