Evidence map›Paper›PMID 32316026›Full record

ArticlePediatric research2021

Genetic variants in the FAM3C gene are associated with lipid traits in Chinese children.

Qiying Song, Jieyun Song, Chenxiong Li, Yang Wang, Lu Qi, Haijun Wang

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In one paragraph

Article in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Qiying SongDepartment of Maternal and Child Health, School of Public Health, Peking University, 100191, Beijing, China.
Jieyun SongInstitute of Child and Adolescent Health, School of Public Health, Peking University, 100191, Beijing, China.
Chenxiong LiDepartment of Maternal and Child Health, School of Public Health, Peking University, 100191, Beijing, China.
Yang WangDepartment of Maternal and Child Health, School of Public Health, Peking University, 100191, Beijing, China.
Lu QiDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
Haijun WangDepartment of Maternal and Child Health, School of Public Health, Peking University, 100191, Beijing, China. whjun@pku.edu.cn.
Peking University · CNTulane University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have related FAM3C gene with childhood bone health, and the regulation of lipid metabolism in hepatocytes. The present case-control study aimed to analyze the association of FAM3C genetic variants with overweight/obesity and lipid traits among Chinese children.

methodsTwo genetic variants (rs7776725 and rs7793554) within the FAM3C gene were genotyped in 3305 Chinese children aged 6-18 years.

resultsIn the whole study population, the T-allele of rs7776725 and A-allele of rs7793554 within the FAM3C gene were associated with 40.2% (95% CI: 11.6-76.1%; P = 0.004) and 29.1% (6.9-56.0%; P = 0.008) increased risk of dyslipidemia, higher triglyceride (P = 0.014 and P = 0.001) and lower HDL-C (P = 0.015 and P = 0.003). In addition, we found that rs7776725 interacted with sex on dyslipidemia (P

conclusionWe found that FAM3C genetic variants were associated with dyslipidemia and lipid traits among Chinese children. In addition, we found significant gene-by-sex interactions. Our findings provided evidence supporting the role of FAM3C gene in regulating lipid metabolism in humans. IMPACT: FAM3C genetic variants were associated with dyslipidemia and lipid traits among Chinese children. In addition, we found significant gene-by-sex interactions. FAM3C/rs7776725 was associated with dyslipidemia and lipid traits only in girls. Our findings provided evidence supporting the role of FAM3C gene in regulating lipid metabolism in humans.

Indexed as

Genetic VariationLipid MetabolismPolymorphism, Single NucleotideAdolescentAllelesAnthropometryCase-Control StudiesChildChinaCholesterol, LDLCytokinesDyslipidemiasFemaleGenotypeHepatocytesHumansCholesterol, LDLCytokinesFAM3C protein, humanNeoplasm ProteinsTriglycerides

Identifiers

PMID32316026
OpenAlexW3017269075

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.