Evidence map›Paper›PMID 32315708›Full record

ArticleBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation2020

Impact of Preemptive Therapy for Cytomegalovirus on Toxicities after Allogeneic Hematopoietic Cell Transplantation in Clinical Practice: A Retrospective Single-Center Cohort Study.

Phaedon Zavras, Yiqi Su, Jiaqi Fang, Anat Stern, Nitasha Gupta, Yuexin Tang, Amit Raval, Sergio Giralt, Miguel Angel Perales, Ann A Jakubowski and 1 more

Open access · greenAbstract read
In one paragraph

Article in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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  12. AURORA: A New Dawn.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Phaedon ZavrasInfectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Yiqi SuInfectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Jiaqi FangInfectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Anat SternInfectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Nitasha GuptaInfectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Yuexin TangCenter for Observational and Real-World Evidence, Merck & Co., Inc., Kenilworth, New Jersey.
Amit RavalCenter for Observational and Real-World Evidence, Merck & Co., Inc., Kenilworth, New Jersey.
Sergio GiraltAdult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York.
Miguel Angel PeralesAdult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York.
Ann A JakubowskiAdult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Genovefa A PapanicolaouInfectious Disease Service, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York. Electronic address: papanicg@mskcc.org.
Memorial Sloan Kettering Cancer Center · USMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

(Val)ganciclovir (vGCV) or foscarnet (FCN) as preemptive therapy (PET) for cytomegalovirus (CMV) after allogeneic hematopoietic cell transplantation (HCT) is associated with myelosuppression and nephrotoxicity, respectively. We analyzed a cohort of CMV-seropositive (R

Indexed as

Cytomegalovirus InfectionsHematopoietic Stem Cell TransplantationAdultAntiviral AgentsCohort StudiesCytomegalovirusGanciclovirHumansRetrospective StudiesAntiviral AgentsGanciclovirAcute kidney injury (AKI)Cytomegalovirus (CMV)FoscarnetGanciclovirHematopoietic cell transplantation (HCT)NeutropeniaPreemptive therapy (PET)Treatment-related toxicityValganciclovir

Identifiers

PMID32315708
PMCPMC8220837
OpenAlexW3016784770

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.