ArticleNeuron2020
Prefrontal Cortex Predicts State Switches during Reversal Learning.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed.
- Acetylcholine: a candidate substrate for hippocampal predictive learning?Nature reviews. Neuroscience · 2026Review
- Perceptual response patterns in rhesus macaque attentional set shifting are associated with inflexible behavior.Cognitive, affective & behavioral neuroscience · 2026Article
- Regime shift detection and neurocomputational substrates for under and overreactions to change.eLife · 2026Article
- Learning to select computations in recurrent neural circuits.bioRxiv : the preprint server for biology · 2026Article
- Prefrontal Mechanisms of Rule Learning.bioRxiv : the preprint server for biology · 2026Article
- Hidden State Inference or Continuous Belief Updating during a Dynamic Visuomotor Skill.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Interaction and functional specialization across a distributed neural circuit for flexible task control in macaques.Nature communications · 2026Article
- Contribution of amygdala to dynamic model arbitration under uncertainty.Nature communications · 2025Article
- Ventral striatal astrocytes contribute to reinforcement learning.bioRxiv : the preprint server for biology · 2025Article
- An Information-Theoretic Framework for Understanding Learning and Choice Under Uncertainty.Entropy (Basel, Switzerland) · 2025Article
- Neural dynamics of reversal learning in the prefrontal cortex and recurrent neural networks.eLife · 2025Article
- Orbitofrontal-Hippocampal State Coding Dynamics during Reversal Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neurobehavioral and metabolic effects of prenatal low-dose chlorpyrifos in C57BL/6J mice.Neurotoxicology · 2025Article
- Higher-order and distributed synergistic functional interactions encode information gain in goal-directed learning.Nature communications · 2025Article
- Article
- Abstract rule learning promotes cognitive flexibility in complex environments across species.Nature communications · 2025Article
- Sample size matters when estimating test-retest reliability of behaviour.Behavior research methods · 2025Article
- Schemas, reinforcement learning and the medial prefrontal cortex.Nature reviews. Neuroscience · 2025Review
- Diminished State Space Theory of Human Aging.Perspectives on psychological science : a journal of the Association for Psychological Science · 2025Article
- The medial and lateral orbitofrontal cortex jointly represent the cognitive map of task space.Communications biology · 2025Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Reinforcement learning allows organisms to predict future outcomes and to update their beliefs about value in the world. The dorsal-lateral prefrontal cortex (dlPFC) integrates information carried by reward circuits, which can be used to infer the current state of the world under uncertainty. Here, we explored the dlPFC computations related to updating current beliefs during stochastic reversal learning. We recorded the activity of populations up to 1,000 neurons, simultaneously, in two male macaques while they executed a two-armed bandit reversal learning task. Behavioral analyses using a Bayesian framework showed that animals inferred reversals and switched their choice preference rapidly, rather than slowly updating choice values, consistent with state inference. Furthermore, dlPFC neural populations accurately encoded choice preference switches. These results suggest that prefrontal neurons dynamically encode decisions associated with Bayesian subjective values, highlighting the role of the PFC in representing a belief about the current state of the world.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.