Evidence map›Paper›PMID 32315541›Full record

ArticleAmerican journal of respiratory cell and molecular biology2020

Multiomics of World Trade Center Particulate Matter-induced Persistent Airway Hyperreactivity. Role of Receptor for Advanced Glycation End Products.

Syed H Haider, Arul Veerappan, George Crowley, Erin J Caraher, Dean Ostrofsky, Mena Mikhail, Rachel Lam, Yuyan Wang, Maria Sunseri, Sophia Kwon and 4 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Update in Adult Asthma 2020.American journal of respiratory and critical care medicine · 2021
    Review
  9. Article
  10. Observational
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Syed H HaiderDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine.
Arul VeerappanDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine.ORCID 0000-0002-6617-5335
George CrowleyDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine.
Erin J CaraherDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine.
Dean OstrofskyDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine.
Mena MikhailDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine.
Rachel LamDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine.ORCID 0000-0002-8731-9481
Yuyan WangDivision of Biostatistics, Department of Population Health.
Maria SunseriDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine.
Sophia KwonDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine.ORCID 0000-0003-3639-5107
David J PrezantBureau of Health Services and Office of Medical Affairs, Fire Department of New York, Brooklyn, New York; and.
Mengling LiuDivision of Biostatistics, Department of Population Health.
Ann Marie SchmidtDiabetes Research Program, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, New York University School of Medicine, New York, New York.
Anna NolanDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine.ORCID 0000-0002-0631-1171
SleepMed · USAlbert Einstein College of Medicine · USNew York City Fire Department · USNew York University · US

Funding

Metabolomics of World Trade Center-Lung Injury: Biomarker Validation, Longitudinal Assessment and Dietary InterventionU01OH011300 · OH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NOLAN, ANNA · 2017 to 2025
$4.8M
RAGE Mediates LPA Induced Pulmonary InflammationR01HL119326 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NOLAN, ANNA · 2015 to 2019
$2.1M
NIOSH CDC HHS U01 OH011300
6 · The paper itself

Abstract

Pulmonary disease after World Trade Center particulate matter (WTC-PM) exposure is associated with dyslipidemia and the receptor for advanced glycation end products (RAGE); however, the mechanisms are not well understood. We used a murine model and a multiomics assessment to understand the role of RAGE in the pulmonary long-term effects of a single high-intensity exposure to WTC-PM. After 1 month, WTC-PM-exposed wild-type (WT) mice had airway hyperreactivity, whereas RAGE-deficient (

Indexed as

Air PollutantsAnimalsAsthmaBronchial HyperreactivityBronchoalveolar Lavage FluidDisease Models, AnimalDustExplosionsFatty AcidsFemaleLungMiceMice, Inbred C57BLParticulate MatterPhosphatidylcholinesReceptor for Advanced Glycation End ProductsAger protein, mouseAir PollutantsDustFatty AcidsParticulate MatterPhosphatidylcholinesReceptor for Advanced Glycation End ProductsSphingolipidsVitamin B 6airway hyperreactivitylung injurymurine modelsoccupational exposureparticulate matter

Identifiers

PMID32315541
PMCPMC7397767
OpenAlexW3016479359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.