ArticleInvestigative ophthalmology & visual science2020
Effect of Changing Heart Rate on the Ocular Pulse and Dynamic Biomechanical Behavior of the Optic Nerve Head.
Article in Investigative ophthalmology & visual science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Pooled it
- Cyclic stretch increases transglutaminase 2-mediated serotonylation of extracellular fibronectin in cultured optic nerve head astrocytes: a pilot study.Matrix biology plus · 2026Article
- Evidence That Cardiac Pulse Strains Retinal Vessels in and near the Optic Disc During Ocular Ductions.Bioengineering (Basel, Switzerland) · 2026Article
- Effect of anticholinergic eye drops on intraorbital, periorbital and brain pulsation power.Acta ophthalmologica · 2025Article
- Compression injury regulates astrocyte morphology, metabolic function, and extracellular matrix modification in a 3D hydrogel.bioRxiv : the preprint server for biology · 2025Article
- Considerations and implications of currentFrontiers in cell and developmental biology · 2025Review
- The Effects of Pregnancy Status on Lacrimal Caruncle Temperature, Intraocular Pressure and Rectal Temperature in Cats: A Preliminary Study.Veterinary medicine and science · 2024Article
- Time-Resolved Dynamic Optical Coherence Tomography for Retinal Blood Flow Analysis.Investigative ophthalmology & visual science · 2024Article
- Denoising OCT videos based on temporal redundancy.Scientific reports · 2024Article
- Medical Application of Geometric Deep Learning for the Diagnosis of Glaucoma.Translational vision science & technology · 2023Article
- Mapping Pulsatile Optic Nerve Head Deformation Using OCT.Ophthalmology science · 2022Article
- Computational Modeling of Ophthalmic Procedures: Computational Modeling of Ophthalmic Procedures.American journal of ophthalmology · 2022Article
- Biomechanical analysis of ocular diseases and its in vitro study methods.Biomedical engineering online · 2022Review
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To study the effect of changing heart rate on the ocular pulse and the dynamic biomechanical behavior of the optic nerve head (ONH) using a comprehensive mathematical model. Methods: In a finite element model of a healthy eye, a biphasic choroid consisted of a solid phase with connective tissues and a fluid phase with blood, and the lamina cribrosa (LC) was viscoelastic as characterized by a stress-relaxation test. We applied arterial pressures at 18 ocular entry sites (posterior ciliary arteries), and venous pressures at four exit sites (vortex veins). In the model, the heart rate was varied from 60 to 120 bpm (increment: 20 bpm). We assessed the ocular pulse amplitude (OPA), pulse volume, ONH deformations, and the dynamic modulus of the LC at different heart rates. Results: With an increasing heart rate, the OPA decreased by 0.04 mm Hg for every 10 bpm increase in heart rate. The ocular pulse volume decreased linearly by 0.13 µL for every 10 bpm increase in heart rate. The storage modulus and the loss modulus of the LC increased by 0.014 and 0.04 MPa, respectively, for every 10 bpm increase in heart rate. Conclusions: In our model, the OPA, pulse volume, and ONH deformations decreased with an increasing heart rate, whereas the LC became stiffer. The effects of blood pressure/heart rate changes on ONH stiffening may be of interest for glaucoma pathology.
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