ArticleJCO global oncology2020
Breast Cancer in Young Women Presents With More Aggressive Pathologic Characteristics: Retrospective Analysis From an Argentine National Database.
Article in JCO global oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 52 citations in OpenAlex.
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- Interleukin-38 serum levels in breast cancer: A comparative analysis of women under 40 and over 50.Caspian journal of internal medicine · 2026Article
- The incidence, clinicopathological characteristics and the survival outcomes among young breast cancer patients in Alexandria, Egypt.Ecancermedicalscience · 2026Article
- Survival deficits in young women with breast cancer in sub-Saharan Africa: the African Breast Cancer-Disparities in Outcomes cohort.Journal of the National Cancer Institute · 2025Article
- Comprehensive survival analysis of breast cancer patients: a bayesian network approach.BMC medical informatics and decision making · 2025Article
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- Main challenges to cancer care in Latin America: an analysis through breast cancer lenses.Lancet regional health. Americas · 2025Review
- How are we allocating physicians to deal with breast cancer in men and women in Brazil?BMC cancer · 2025Article
- Survival Following CDK4/6 Inhibitor Therapy for Hormone Receptor-Positive, ERBB2-Negative Metastatic Breast Cancer.JAMA network open · 2025Article
- Pathway to care among adolescents and young adults with breast cancer in Nigeria: a mixed methods study.BMC cancer · 2025Article
- Clinical profile and outcomes of young women with denovo-metastatic breast cancer: real-world data from a tertiary care centre in India.Ecancermedicalscience · 2025Article
- Clinicopathological Evaluation of Patients with Hormone Receptor-Positive HER2-Negative Metastatic Breast Cancer Progressing on Endocrine Treatment: A Real-World Retrospective Study from a Regional Cancer Center.South Asian journal of cancer · 2025Article
- Trends in age-specific incidence, mortality, and DALYs of female breast cancer from 1990 to 2021.Aging medicine (Milton (N.S.W)) · 2024Article
- Vitamin D and Breast Cancer Risk: Evaluating the Association and Effective Risk Reduction.Breast care (Basel, Switzerland) · 2024Article
- Postpartum Breast Cancer and Survival in Women With Germline BRCA Pathogenic Variants.JAMA network open · 2024Article
- Suffering and adjustment: a grounded theory of the process of coping with financial toxicity among young women with breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
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15 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeMultiple studies have reported that breast cancer in young patients is associated with aggressive characteristics, and it is suggested that prognosis is worse independently of pathologic variables. PATIENTS AND
methodsWe performed a retrospective analysis of the Breast Cancer Registry of the Argentinian Society of Mastology, including public and private centers. Patients ≤ 40 years of age at diagnosis were classified as "young," and patients ≤ 35 years of age at diagnosis were classified as "very young." Univariate and multivariate analyses were performed to detect differences between groups.
resultsPatients ≤ 40 years of age comprised 10.40% (739/7,105) of the participants, with an average age of 35.61 ± 4.04 years. Multivariate analysis showed that human epidermal growth factor receptor 2 (HER2)-positive tumor phenotype (odds ratio [OR], 1.82), nodal involvement (OR, 1.69), histologic grade (grade 3 OR, 1.41), and tumor size (T2 OR, 1.37; T3-T4, 1.47) were independently associated with younger age at diagnosis. Patients ≤ 35 years of age (n = 286), compared with patients 36 to 40 years of age, had a higher proportion of HER2 tumors (24.58%
conclusionIn the population studied, breast cancer in young women was associated with aggressive pathologic features and locally advanced disease at the time of diagnosis. Moreover, tumor characteristics in very young patients with breast cancer nested in the population ≤ 40 years of age showed differences in important prognostic factors. More high-quality evidence is needed to improve treatment strategies in these patients.
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