Evidence map›Paper›PMID 32315227›Full record

ArticleThe CRISPR journal2020

ErCas12a CRISPR-MAD7 for Model Generation in Human Cells, Mice, and Rats.

Zhenyi Liu, John A Schiel, Elena Maksimova, Žaklina Strezoska, Guojun Zhao, Emily M Anderson, Yumei Wu, Joe Warren, Angela Bartels, Anja van Brabant Smith and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The CRISPR journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
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  11. Comparison of CRISPR-MAD7 and CRISPR-Cas9 for Gene Disruptions inJournal of fungi (Basel, Switzerland) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Zhenyi LiuENVIGO Research Model Services (Formerly Horizon Discovery Group), St. Louis, Missouri, USA.
John A SchielHorizon Discovery Group Company, Lafayette, Colorado, USA.
Elena MaksimovaHorizon Discovery Group Company, Lafayette, Colorado, USA.
Žaklina StrezoskaHorizon Discovery Group Company, Lafayette, Colorado, USA.
Guojun ZhaoENVIGO Research Model Services (Formerly Horizon Discovery Group), St. Louis, Missouri, USA.
Emily M AndersonHorizon Discovery Group Company, Lafayette, Colorado, USA.
Yumei WuENVIGO Research Model Services (Formerly Horizon Discovery Group), St. Louis, Missouri, USA.
Joe WarrenENVIGO Research Model Services (Formerly Horizon Discovery Group), St. Louis, Missouri, USA.
Angela BartelsENVIGO Research Model Services (Formerly Horizon Discovery Group), St. Louis, Missouri, USA.
Anja van Brabant SmithHorizon Discovery Group Company, Lafayette, Colorado, USA.
Chris E LoweWaterbeach, Cambridge, United Kingdom.
Kevin P ForbesENVIGO Research Model Services (Formerly Horizon Discovery Group), St. Louis, Missouri, USA.
Horizon Discovery Group (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MAD7 is an engineered class 2 type V-A CRISPR-Cas (Cas12a/Cpf1) system isolated from

Indexed as

AnimalsBacterial ProteinsClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Associated ProteinsCRISPR-Cas SystemsDNAEndodeoxyribonucleasesEndonucleasesEubacteriumGene EditingGenomeHCT116 CellsHumansMiceRatsRNA, Guide, CRISPR-Cas SystemsBacterial ProteinsCas12a proteinCRISPR-Associated ProteinsDNAEndodeoxyribonucleasesEndonucleasesRNA, Guide, CRISPR-Cas Systems

Identifiers

PMID32315227
PMCPMC7194332
OpenAlexW3017375603

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.