Evidence map›Paper›PMID 32315115›Full record

ArticleChemMedChem2020

Iminodiacetic Acid as a Novel Metal-Binding Pharmacophore for New Delhi Metallo-β-lactamase Inhibitor Development.

Allie Y Chen, Caitlyn A Thomas, Pei W Thomas, Kundi Yang, Zishuo Cheng, Walter Fast, Michael W Crowder, Seth M Cohen

Open access · greenAbstract read
In one paragraph

Article in ChemMedChem, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Machine Learning Models Identify Inhibitors of New Delhi Metallo-β-lactamase.Journal of chemical information and modeling · 2024
    Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Chemical communications (Cambridge, England) · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Allie Y ChenDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
Caitlyn A ThomasDepartment of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA.
Pei W ThomasDivision of Chemical Biology & Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, Austin, TX 78712, USA.
Kundi YangDepartment of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA.
Zishuo ChengDepartment of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA.
Walter FastDivision of Chemical Biology & Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, Austin, TX 78712, USA.ORCID 0000-0001-7567-2213
Michael W CrowderDepartment of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA.ORCID 0000-0002-3138-0283
Seth M CohenDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0002-5233-2280
Miami University · USAustin College · USUniversity of California San Diego · US

Funding

Developing Metallo-Beta-Lactamase InhibitorsR01GM111926 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI BONOMO, ROBERT A., COHEN, SETH M · 2015 to 2019
$2.3M
Insight and Optimization of Metalloprotein InhibitorsR01GM098435 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THEODORAKIS, EMMANUEL A · 2011 to 2018
$2.2M
Machine Learning Approach for finding novel metallo-b-lactamase inhibitorsR15GM134454 · NIGMS · MIAMI UNIVERSITY OXFORD · PI CROWDER, MICHAEL W · 2019 to 2022
$867k
NIGMS NIH HHS R01 GM098435NIGMS NIH HHS R01 GM111926NIGMS NIH HHS R15 GM134454
6 · The paper itself

Abstract

The fungal natural product aspergillomarasmine A (AMA) has been identified as a noncompetitive inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1) that inhibits by removing Zn

Indexed as

beta-Lactamase Inhibitorsbeta-LactamasesCoordination ComplexesDose-Response Relationship, DrugHumansImino AcidsMolecular StructureStructure-Activity RelationshipZincbeta-Lactamase Inhibitorsbeta-lactamase NDM-1beta-LactamasesCoordination ComplexesImino Acidsiminodiacetic acidZincantibiotic resistanceaspergillomarasmine Aiminodiacetic acidmetal chelatorNew Delhi metallo-β-lactamase

Identifiers

PMID32315115
PMCPMC7434514
OpenAlexW3016358025

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.